Ektoinin İnsan Lenfosit Hücrelerinde Genotoksik Potansiyeli

Ektoin EKT , halofil bakterilerin stres faktörlerine karşı olarak ürettiği bir ozmoprotektandır. Bu amino asit türevi madde, doğal proseslere müdahale etmeden yüksek konsantrasyonlarda hücreler içinde birikebilir ve hücrenin radyasyona ya da ozmotik strese karşı korunmasına yardımcı olabilir. EKT, farklı alanlardaki yoğun uygulamalarından dolayı bilim adamlarının ilgisini kazanmaktadır. Bu çalışmada, insan lenfosit hücrelerini kullanarak, EKT’nin genotoksik ve anti-genotoksik potansiyellerini incelemeyi amaçladık. Sonuçlar, EKT’nin güçlü antigenotoksik özelliğe sahip olduğunu gösterdi. Ayrıca bulgularımız NaN3’e maruz bırakılan insan lenfosit hücrelerinde gözlemlenen koruyucu etkinin, EKT’nin antioksidatif özellikleriyle ilişkili olabileceğini düşündürmektedir

Anahtar Kelimeler:

Ektoin, Genotoksisite, Komet testi, Lenfosit hücreleri

Genotoxic Potential of Ectoine in Human Lymphocyte Cells

Ectoine ECT is an osmoprotectant produced by halophilic bacteria in response to stressful factors. This amino acid derivative material can accumulate inside cells at high concentrations without interfering with natural processes and can protect the cell against radiation or osmotic stress. ECT is receiving increasing awareness by the scientific community because of its multiple applications. In the present study, we aimed to investigate the genotoxic and anti-genotoxic potencies of ECT by using human lymphocytes cells. The results showed that ECT has strong anti-genotoxic properties. Also, our findings suggest that protective effects of ECT in human lymphocytes cells subjected to NaN3 may be related to antioxidative properties of the ECT.

Keywords:

Ektoin, Komet Testi, Lenfosit Hücreleri, Genotoksisite,

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