Nurhan GÜMRÜKÇÜOĞLU, Bahar BİLGİN SÖKMEN

Yeni Antioksidanlar Olarak Bazı 2,5-Disübstitüye-1,3,4-Oksadiazoller

Birçok heterosiklik bileşik, farmakolojik açıdan önemli olan yeni yapıların sentezi için başlangıç bileşiği olarak kullanılmaktadır. Bunlardan azol gurubu bileşikler, sahip oldukları değişik biyolojik aktivitelerden dolayı son yıllarda sıklıkla sentezlenen bileşik sınıfları haline gelmiştir. Beş üyeli halka içeren heterosiklik bileşikler, farmakolojik özelliklere sahip olmasından dolayı son yıllarda popüler bileşikler sınıfına girmiştir. Bu çalışmada, bazı 2,5-disübstitüye-1,3,4-oksadiazollerin (1-3) antioksidan aktiviteleri, ABTS (2,2’-Azino-bis(3-etilbenzenothiazoline-6-sülfonik asid), DPPH (1,1-difenil-2-pikrilhidrazil) radikal giderme aktiviteleri ve demir indirgeme gücü kapasitesine göre incelendi. Elde edilen sonuçlar, sentezlenen bileşiklerin (1-3) etkili antioksidan aktiviteye sahip olduğunu gösterdi.

Anahtar Kelimeler:

2.5-Disübstitüye-1.3.4-oksadiazoller, Antioksidan, ABTS Radikal Giderme Aktivitesi

Some 2,5-Disubstitue-1,3,4-Oxadiazoles as New Antioxidants

Many heterocyclic compound, a pharmacologically used as the starting compound for the synthesis of new structures which are important. Groups of these azole compounds, due to their various biological activities, in recent years have become common classes of compounds synthesized. Heterocyclic compounds containing five-membered ring, compounds of pharmacological class have entered popular in recent years due to properties. In this study, antioxidant activities of some 2,5-disubstitue-1,3,4-oxadiazoles (1-3) were evaluated for according to ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities and iron reducing power capacity. The obtained results showed that the synthesized compounds (1-3) had effective antioxidant activities.

Keywords:

2.5-Disubstitue-1.3.4-oxadiazoles, Antioxidant, ABTS Radical Scavenging Activity,

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