Concentration of heavy metals (Cu, Zn, Fe, Pb, Cd, Cr, Ni) determined in the muscle, liver, kidney and gills of talang queenfish, Scomberoides commersonnianus. Sixty three fish samples collected seasonally from Karachi coast in Jan 2010-Dec 2010 . Samples were analyzed by AAS-700. Results shown highest mean concentration of Fe (495.73), Cu (47.64) Cd (1.59), Cr (1.63), Ni (1.55) and Pb (1.65) were determined in liver, Zn (48.98) in kidney in µg/g. Lowest mean concentrations of Fe (16.55), Zn (5.31), Cu (4.57) were estimated in muscles, Cd (1.59) in liver, Cr (0.38), Ni (0.50), Pb (0.48) in gills in µg/g. Fe, Zn, Cu were higher in liver, kidney and gills and Cd, Cr, Ni, Pb were lowest in muscles, kidney and gills during all seasons. ANOVA analysis clearly revealed that there was a significant different in organs and seasons in fish