Bazı Yeni Antipirin Karbo (tiyo) amid ve 1,2,4-Triazol Türevlerinin Sentezi ve Anti-tuberküler Aktivitelerinin Karşılaştırılması

Bu çalışmada antipirin (4-Aminoantipirin) başlangıç maddesi olarak seçilerek karbotiyoamit ve 1,2,4-triazoltürevi bileşikler gerçekleştirilerek anti-tuberküler aktiviteleri karşılaştırılmıştır. 4-aminoantipirin sırasıyla etilbromoasetat, hidrazinhidrat ve çeşitli izo(tiyo)siyanatlar ile muamelesi sonucu bazik ortamda reaksiyonu ile halkalaşma reaksiyonu gerçekleşmesi ile yapıya ikinci bir halka olan 1,2,4-triazol halkasının ilavesi gerçekleştirildi. Sentezlenen yeni antipirin türevi bileşiklerin yapıları IR, NMR ve kütle spektrofotometresi gibi spektroskopik yöntemlerle aydınlatıldı. Sentezlenen yeni bileşikler, Gram olmayan bakteriye karşı aktivite çalışmaları gerçekleştirilmiştir.

Anahtar Kelimeler:

Antipirin, 1 2 4-Triazol, Anti-tuberküler Aktivite

Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities

In this study, antipyrine (4-aminoantipyrine) was selected as the starting material and anti-tubercular activities were compared by carrying out the antipyrine nucleated carbothioamide and 1,2,4-triazole derivatives. The treatment of 4-aminoantipyrine with ethylbromoacetate, hydrazinhydrate and various iso (thio) cyanates, respectively, followed by cyclic reaction by basic reaction resulted in the addition of a second ring of 1,2,4-triazole to the structure. The structures of the synthesized new antipyrine derivatives were determined by spectroscopic methods such as IR, NMR and mass spectrophotometry. For the new compounds synthesized, activity studies were performed against non-Gram bacteria.

Keywords:

Antipyrine, 1 2 4-Triazole, Anti-tubercular Activity,

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