İnme Hastalarında Tam Kan Sayımı Parametreleri Fonksiyonel Seviyeyi Gösterir mi?

Amaç: İnflamasyon, inme patogenezinde çok önemli bir role sahiptir, son yıllarda tam kan parametre ve türevleri çeşitli hastalıkların seyrinde kötü prognoz kriteri olarak yol gösterici bulunmaktadır. Burada çeşitli tam kan parametre ve türevlerinin inmeli hastaların fonksiyonel seviyeleriyle ilişkisini ortaya koymayı amaçladık.Gereç ve Yöntem: Kliniğimize 2016-2017 yılları arasında yatarak tedavi gören inme tanılı hastalar retrospektif olarak analiz edildi. Tüm hastaların yaş, cinsiyet, etiyoloji, tutulan taraf, spastisite varlığı, fonksiyonel ambulasyon seviyeleri (FAS), üst ve alt ekstremite Brunnstrom evreleri kayıt edildi. Tüm hastaların yatış sırasındaki tam kan sayısı ve alt parametreleri, beyaz küre (WBC), eritrosit dağılım genişliği (RDW), platelet dağılım genişliği (PDW), ortalama platelet volüm (MPV) ile akut faz reaktanları, eritrosit sedimentasyon hızı (ESR), C-reaktif protein (CRP) kayıt edildi. Bulgular: Çalışmamıza 32-85 yaş aralığında 55 erkek (% 63.2), 30 kadın (% 34.5) hasta dahil edildi. Hastaların % 64’ü 1 yıldan kısa süre inme tanılı, % 86.2’si iskemik, % 50.6’sı sağ taraf tutulumlu idi. Hastaların % 25.3’ünde spastisite yoktu. Spastisite gözlenenler içinde en sık % 23 oranı ile Ashworth evre 1 spastisite gözlendi. Fonsiyonel düzeyleri en sık % 20.7 oranı ile FAS 3, üst ekstremite % 32.2 oranı ile Brunnstrom evre 3, alt ekstremitede % 28.7 oranı ile Brunstrom evre 5 seviyede idi. Sonuç: İnflamasyon parametreleri inmeli hastalarda fonksiyonel seviye hakkında bilgi vermektedir. İnflamatuar reaksiyonu tetikleyen sistemik inflamasyonu veya nöronal yolların inhibisyonu inme hastalarında gelecekteki potansiyel tedavi hedefleridir.

Anahtar Kelimeler:

inme, nöroinflamasyon, fonksiyonel seviye

Do Complete Blood Count Parameters Show the Functional Level in Stroke Patients?

Objective: Inflammation has a crucial role in the pathogenesis of stroke, and in recent years, complete blood parameters and their derivatives have led to poor prognosis in the course of various diseases. We aimed to elucidate the relation of various whole blood parameters and derivatives with the functional levels of stroke patients. Matherial and Methods: Patients diagnosed with stroke in our clinic between 2016 and 2017 years were retrospectively analyzed. All patients were recorded for age, gender, etiology, involved side, spasticity, functional ambulatory scale (FAS), upper and lower extremity Brunnstrom grades. Acute phase reactants, erythrocyte sedimentation rate (ESR), C-reactive protein (RBC), and complete blood count and sub-parameters of all patients at the time of admission, white blood cell (WBC), erythrocyte distribution width (RDW), platelet distribution width (PDW), mean platelet volume reactive protein (CRP) were recorded. Results: Fifty-five (55) male (63.2%) and 30 female (34.5%) were included in the study at the age range of 32-85 years. Sixty-four percent (64%) of the patients were diagnosed with stroke for less than 1 year, 86.2% was ischemic, and 50.6% was right-sided. There was no spasticity in 25.3% of the patients. Ashworth grade 1 spasticity was the most frequently observed in 23% of the cases with spasticity. Functional levels were most frequently with a ratio of 20.7% FAS 3, upper extremity with a ratio of 32.2% was Brunnstrom grade 3, at lower extremity was Brunstrom grade 5 with a ratio of 28.7%. Conclusion: Inflammatory parameters provide information about the functional level in stroke patients. Systemic inflammation that triggers an inflammatory reaction or inhibition of neuronal pathways is a potential future therapeutic target in stroke patients.therapeutic target in stroke patients.

Keywords:

stroke, neuroinflammation, functional level,

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