Özlem GÜLER, Buket TUĞAN YILDIZ, Hakan HAKKOYMAZ, Süleyman AYDIN, Meltem YARDIM

Akut İskemik İnme Hastalarında Serum ve İdrar Katekolaminerjik ve Apelinerjik Sistem Üyelerinin Düzeyleri

Amaç: Akut iskemik inmeli hastalarda ve sağlıklı kontrollerde katekolaminerjik sistem üyeleri renalaz, serebellin ve bunların substratları epinefrin, norepinefrin ve dopamin ile apelinerjik sistem üyeleri apelin, elabela ve nitrik oksit düzeylerinin kan ve idrarda karşılaştırılması. Gereç ve Yöntemler: Akut iskemik inmeli 42 hasta ile yaş ve cinsiyet açısından eşleştirilmiş 42 sağlıklı kontrol çalışmaya dahil edildi. Kan ve idrar örnekleri akut inme klinik belirtilerinin başlangıcından sonraki ilk 24 saat içinde eş zamanlı olarak toplandı ve ELISA yöntemi kullanılarak ölçüldü. Bulgular: İskemik inme ve kontrol gruplarında serum ve idrar serebellin, renalaz, epinefrin, norepinefrin, dopamin, apelin, elebela ve nitrik oksit düzeyleri benzerdi (P>0.05). Hem inmeli hastalarda hem de kontrollerde serum ve idrarda renalaz, serebellin ve katekolamin düzeyleri arasında güçlü korelasyonlar bulundu (p <0.001). İki grupta da serum ve idrarda apelin, elabela ve NO düzeyleri arasında güçlü korelasyonlar vardı (p<0.001). Sonuç: İskemik inmenin akut fazında serum ve idrar serebellin, renalaz, epinefrin, norepinefrin, dopamin, apelin, elebela ve nitrik oksit düzeyleri önemli ölçüde değişmemektedir. Renalaz, serebellin ve katekolaminler arasındaki güçlü korelasyonlar, bu maddelerin sağlıklı bireylerde ve iskemik inmeli hastalarda birlikte hareket ettiğini vurgulamaktadır. Benzer şekilde, apelin, elabela ve NO arasındaki güçlü korelasyonlar, bu ajanların sağlıklı kişilerde ve iskemik inmeli hastalarda birlikte hareket ettiğini göstermektedir.

Anahtar Kelimeler:

iskemik inme, renalaz, serebellin, epinefrin, norepinefrin, dopamin, apelin, elabela, nitrik oksit

Levels of Serum and Urine Catecholaminergic and Apelinergic System Members in Acute Ischemic Stroke Patients

Objective: To compare levels of catecholaminergic system members, renalase, cerebellin, and their substrates, epinephrine, norepinephrine, and dopamine, and apelinergic system members, apelin, elabela, and nitric oxide in the blood and urine of patients with acute ischemic stroke and healthy controls. Materials and Methods: 42 patients with acute ischemic stroke and 42 age and sex-matched healthy controls were included in the study. Blood and urine samples were collected simultaneously and within the first 24 hours after the onset of acute stroke clinical manifestations and were measured using an ELISA method. Results: The levels of serum and urine cerebellin, renalase, epinephrine, norepinephrine, dopamine, apelin, elebela, and nitric oxide were similar in ischemic stroke and in control groups (P>0.05). Strong correlations were found between renalase, cerebellin, and catecholamine levels in serum and urine (p <0.001) both in stroke patients and controls. There were also strong correlations between apelin, elabela, and NO levels in serum and urine (p <0.001) in the two groups. Conclusion: Serum and urine cerebellin, renalase, epinephrine, norepinephrine, dopamine, apelin, elebela, and nitric oxide levels do not significantly change in the acute phase of ischemic stroke. Strong correlations among renalase, cerebellin, and catecholamines emphasize that these substances act together in healthy individuals and ischemic stroke patients. Similarly, strong correlations between apelin, elabela, and NO indicate that these agents act together in healthy subjects and patients with ischemic stroke.

Keywords:

ischemic stroke, renalase, cerebellin, epinephrine, norepinephrine, dopamine, apelin, elabela, nitric oxide,

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