Metehan UZUN, Mehmet KARACA, Birkan TOPÇU, Yunus KURT

Tavşanlarda damar içi oksitosin ve metil ergonovin enjeksiyonunun QT süresi üzerine etkileri

Bu araştırma ile tavşanlara oksitosin (OKS) ve metil ergonovinin (ME) yalnız başlarına veya birlikte enjeksiyonları sonrası kalp atım sayısı (KA), QT ve QTc değerlerindeki değişimlerin araştırılması amaçlanmıştır. Bu amaçla her bir grupta 6 tavşan olacak şekilde 9 grup oluşturulmuş ve enjeksiyonlar yapılmıştır [1. grup (0.5 U OKS/tavşan), 2. grup (1 U OKS/tavşan), 3. grup (3 U OKS/tavşan), 4. grup (0.1 mg ME/tavşan), 5. grup (0.2 mg ME/tavşan), 6. grup (0.3 mg ME/tavşan), 7. grup (0.5 U OKS + 0.1 mg ME/tavşan), 8. grup (1 U OKS + 0.2 mg ME/tavşan) ve 9. grup (3 U OKS + 0.3 mg ME/tavşan)]. Enjeksiyon öncesi ve enjeksiyon sonrası 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18 ve 20. dakikalarda EKG kayıtları alınmıştır. Elektrokardiyogram kayıtlarından KA, QT ve QTc değerleri hesaplanmıştır. Oksitosinin yalnız başına veya ME ile birlikte uygulandığı gruplarda enjeksiyon sonrası KA değerleri istatistiksel olarak anlamlı şekilde azalmıştır (P

Anahtar Kelimeler:

elektrokardiyogram, kalp hızı, oksitosin, tavşan

The effects of intravenous oxytocin and methylergonovine administration on QT interval in rabbits

The aim of this study was to evaluate changes in heart rate (HR), QT, and QTc values in conscious female New Zeland rabbits which intravenously received oxytocin (OXT), methylergonovine (ME) and OXT plus ME at different dosages. Animals were divided in to 9 equal groups; Group 1 (n=6, received 0.5 U OXT per animal), group 2 (n=6, received 1 U OXT per animal), group 3 (n=6, received 3 U OXT per animal), group 4 (n=6, 0.1 mg ME per animal), group 5 (n=6, received 0.2 mg ME per animal), group 6 (n=6, received 0.3 mg ME per animal), group 7 (n=6, received 0.5 U OXT + 0.1 mg ME per animal), group 8 (n=6, received 1 U OXT + 0.2 mg ME per animal) and group 9 (n=6, received 3 U OXT + 0.3 mg ME per animal). Electrocardiographical recording were taken from all animals before injection and then at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18 and 20. minutes of each drug administration. The HR, QT and QTc values were estimated from ECG recording. The HR values decreased in OXT and OXT plus ME injected groups (P<0.001). In these groups prolongation of QT and QTc intervals were observed after drug injection during the 1-3 minutes (P<0.001). There were not determined significant changes of all observed parameters in ME injected groups. In conclusion, it should be taken into consideration by the physicians QT prolongation and short-term and serious bradycardia due to OXT application. The results of the study also suggest that ME may be safer than OXT in terms of HR and QT intervals.

Keywords:

electrocardiograms, heart rate, oxytocin, rabbits,

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