Ognjen STEVANCEVIC, Nenad STOJANAC, Aleksandar POTKONJAK, Milovan GAGRCIN, Bozidar SAVIC, Ivan STANCIC, Vuk VRACAR

Immune response and production perfomance in piglets vaccinated at 15 and 21 days old against circovirus infection

Bu incelemenin amacı, PCV2 Virüsüne özel antikor titresi seviyesine ve domuzların üretim özelliklerine aşılamanın etkisini belirlemektir. Birinci, A grubu, 15 günlükken aşı olmuştur, ikinci (B), 21 günlükken, üçüncü, C grubu ise, kontrol grubuydu. B grubu domuz yavrularında çok daha iyi sonuçlar alınmıştır. Dolayısıyla, domuz yavrularının 21 günlükken aşılanmasının, 15 günlükken yapılan aşılamadan daha başarılı olduğu anlaşılmıştır. Ancak, belirtmek gerekir ki maternal antikorların, 15 günlük olan domuz yavrularının kendi bağışıklık yanıtının gelişmesi ve oluşması üzerine etkisi çok daha büyüktür.

Domuzlarda circovirus enfeksiyonuna karşı 15 ve 21 günlükken aşı olan domuz yavrularının bağışıklık yanıtı ve üretim performansı

The aim of this research was to determine the effect of vaccination on the amount of antibody titers specific for PCV2, and to determine the effect of vaccination on characteristics of pig production. The first group (A) was vaccinated at 15 days old, the second (B) at 21 days old while the third (C) was the control group. Group B piglets attained the best results, so the vaccination of piglets at 21 days old would have an advantage compared to vaccination at 15 days old, although we note that at 15 days old, there is a far greater influence of maternal antibodies on the creation and development of immune responses in the piglets after vaccination.

PDF

___

1. Llorenç Grau-Romaa, Frailea L, Segalésa J: Recent advances in the epidemiology, diagnosis and control of diseases caused by porcine circovirus type 2. Vet J, 187 (1): 23-32, 2011.
2. Allan GM, McNeilly F, Cassidy JP, Reilly GAC, Adair B, Ellis WA, McNulty MS: Pathogenesis of porcine circovirus; experimental infections of colostrum deprived piglets and examination of pig foetal material. Vet Microbiol, 44 (1): 49-64, 1995.
3. Segalés J: Porcine circovirus type 2 (PCV2) infections: Clinical signs, pathology and laboratory diagnosis. Virus Res, 164 (1-2): 10-19, 2012.
4. Lyoo K, Joo H, Caldwell B, Kim H, Davies PR, Torrison J: Comparative efficacy of three commercial PCV2 vaccines in conventionally reared pigs. Vet J, 189 (1): 58-62, 2011.
5. Nathan MB, Xiang-Jin M: Efficacy and future prospects of commercially available and experimental vaccines against porcine circovirus type 2 (PCV2). Virus Res, 164 (1-2): 33-42, 2012.
6. Martelli P, Ferrari L, Morganti M, De Angelis E, Bonilauri P, Guazzetti S, Caleffi A, Borghetti P: One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions. Vet Microbiol, 149 (3-4): 339-351, 2011.
7. Opriessnig T, Patterson AR, Madson DM, Pal N, Halbur PG: Comparison of efficacy of commercial one dose and two dose PCV2 vaccines using a mixed PRRSV-PCV2-SIV clinical infection model 2-3- months post vaccination. Vaccine, 27 (7): 1002-1007, 2009.
8. Fort M, Fernandes LT, Nofrarias M, Diaz I, Sibila M, Pujols J, Mateu E, Segales J: Development of cell-mediated immunity to porcine circovirus type 2 (PCV2) in caesarean-derived, colostrum-deprived piglets. Vet Immunol Immunopathol, 129 (1-2): 101-107, 2009.
9. Krakowka S, Ellis JA, McNeilly F, Ringler S, Rings DM, Allan G: Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet Pathol, 38 (1): 31-42, 2001.
10. Opriessnig T, Xiang-Jin M, Halbur P: Porcine Circovirus type 2- associated disease: Update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J Vet Diagn Invest, 19 (6): 591-615, 2007.
11. Meerts P, Van GS, Cox E, Vandebosch A, Nauwynck HJ: Correlation between type of adaptive immune response against porcine circovirus type 2 and level of virus replication. Viral Immunol, 18 (2): 333-341, 2005.
12. Bolin SR, Stoffregen WC, Nayar GPS, Hamel AL: Postweaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirus. J Vet Diagn Invest, 13 (3): 85-194, 2001.
13. Rovira A, Balasch M, Segales J, Garcia L, Plana-Duran J, Rosell C, Ellerbrok H, Mankertz A, Domingo M: Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. J Virol, 76 (7): 3232-3239, 2002.
14. Fort M, Olvera A, Sibila M, Segalés J, Mateu E: Detection of neutralizing antibodies in postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs. Vet Microbiol, 125 (3-4): 244-255, 2007.
15. Ritzmann M, Palzer A, Eddicks M, Elicker S, Heinritzi K: Lack of interference with maternal immunity and reduction of viremia in PCV2 vaccinated pigs. 20th International Pig Veterinary Society Congress. June 22- 26, Durban South Africa, p.95, 2008.