Maryam KARIMI DEHKORDI, Ali KADIVAR, Taghi TAKTAZ HAFSHEJANI

6981

Critical Thresholds of Nonesterified Fatty Acids and ?-hydroxybutyrate in Transition Dairy Cows for Prediction of First Service Conception Rate

Bu çalışmanın amacı ineklerde ilk tohumlamada gebe kalma oranını tahmin etmede ?-hidroksibütrat (BHBA) ve esterlenmemiş yağ asitleri (NEFA) kritik eşik değerlerini belirlemektir. Çalışmanın verileri ticari büyük bir çiftlikte 97 adet Holstein ırkı inekten (2 ile 5 parite) elde edildi. Tüm ineklerde BHBA ve NEFA serum konsantrasyonları prepartum 10. günde ve postpartum 1, 2, 4 ve 6. haftalarda ölçüldü. BHBA ve NEFA ilk tohumlamada gebe kalma eşik değerini belirlemek amacıyla Receiver Operator Characteristic (ROC) ile analiz edildi. Postpartum 4. ve 6. haftalardaki NEFA ROC analizinde belirlenen tek anlamlı değerlerdi. 4. ve 6. haflarda NEFA için optimal kritik eşik değerleri sırası ile 201.15 µmol/L ve 203.4 µmol/L olarak tespit edildi (P=201.15 ineklerde (OR=0.176; P=0.001) %82.4 ve 6. haftada NEFA >=203.4 µmol/L ineklerde (OR=0.114; P=0) %88.6 daha düşük olarak belirledi. Sonuç olarak, doğumdan sonra 4 ve 6. haftalarda NEFA konsantrasyonları ilk suni tohumlamada gebe kalma olasılığı ile düşük derecede ilişkilidir.

Geçiş Dönemi Sütçü İneklerde İlk Tohumlamada Gebe Kalma Oranını Tahmin Etmede Esterlenmemiş Yağ asitleri ve ?-hidroksibütirat Kritik Eşik Değerleri

The objective of this study was to establish cow level critical thresholds for ?-hydroxybutyrate (BHBA) and nonesterified fatty acids (NEFA) to predict conception to first service. The data were generated from 97 Holstein cows (2 to 5 parities) on a large commercial farm. Serum concentrations of BHBA and NEFA were measured in all cows on day 10 prepartum and, weeks 1, 2, 4 and 6 postpartum. NEFA and BHBA analyzed with receiver operator characteristic (ROC) analysis to determine critical thresholds for predicting pregnancy to first service. NEFA in weeks 4 and 6 postpartum were the only significant predictors identified in the ROC analysis. Optimum critical thresholds for NEFA in weeks 4 and 6 were 201.15 µmol/L and 203.4 µmol/L, respectively (P<0.05). The critical threshold for serum BHBA in the prepartum cohort was 600 µmol/L (P=0.1), which predicted conception to first service. Logistic regression analysis indicated that the risk of conceiving was 82.4% and 88.6% lower for cows with NEFA >=201.15 in week 4 (OR=0.176; P=0.001) and NEFA >=203.4 µmol/L in week 6 (OR=0.114; P=0), respectively. In conclusion, NEFA concentrations within 4 and 6 weeks after calving were associated with lower probability of pregnancy at the first AI.

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  • Gerloff BJ: Dry cow management for the prevention of ketosis and fatty liver in dairy cows. Vet Clin North Am: Food Anim Pract 16, 283-292, DOI: 10.1016/S0749-0720(15)30106-7
  • Hayirli A, Grummer RR, Nordheim EV, Crump PM: Animal and dietary factors affecting feed intake during the prefresh transition period in Holsteins. J Dairy Sci, 85, 3430-3443, 2002. DOI:  10.3168/jds.S0022- (02)74431-7
  • Drackley JK, Overton TR, Douglas GN: Adaptations of glucose and long chain fatty acid metabolism in liver of dairy cows during the periparturient period. J Dairy Sci, 84 (E Suppl.): E100-E112, 2001. DOI: 10.3168/jds.S0022-0302(01)70204-4
  • Hegardt FG: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: A control enzyme in ketogenesis. Biochem J, 338, 569-582, 1999. DOI: 1042/bj3380569
  • LeBlanc SJ, Leslie KE, Duffield TF: Metabolic predictors of displaced abomasum in dairy cattle. J Dairy Sci, 88, 159-170, 2005. DOI: 10.3168/jds. S0022-0302(05)72674-6
  • Ospina PA, Nydam DV, Stokol T, Overton TR: Evaluation of nonesterified fatty acids and ?-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. J Dairy Sci, 93, 546-554, 2010. DOI: 10.3168/jds.2009-2277
  • Walsh RB, Walton JS, Kelton DF, LeBlanc SJ, Leslie KE, Duffield TF: The effect of subclinical ketosis in early lactation on reproductive performance of postpartum dairy cows. J Dairy Sci, 90, 2788-2796, 2007. DOI: 10.3168/jds.2006-560
  • Ospina PA, Nydam DV, Stokol T, Overton TR: Associations of elevated nonesterified fatty acids and ?-hydroxybutyrate concentrations with early lactation reproductive performance and milk production in transition dairy cattle in the northeastern United States. J Dairy Sci, 93, 1603, 2010. DOI: 10.3168/jds.2009-2852
  • Duffield TF, Lissemore KD, McBride BW, Leslie KE: Impact of hyperketonemia in early lactation dairy cows on health and production. J Dairy Sci, 92, 571-580, 2009. DOI: 10.3168/jds.2008-1507
  • Greiner M, Pfeiffer D, Smith RD: Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Prev Vet Med, 45, 23-41, 2000. DOI: 10.1016/S0167-5877(00)00115-X
  • Swets JA: Measuring the accuracy of diagnostic systems. Science, , 1285-1293, 1988. DOI: 10.1126/science.3287615
  • Kadivar A, Ahmadi MR, Gheisari HA, Nazifi S: Relationship among Insulin-Like Growth Factor I some metabolite concentrations in prepartum and Reproductive function in Holstein Friesian dairy cows. Comp Clin Pathol, 21 (5): 589-596, 2012.
  • Chapinal N, Carson ME, LeBlanc SJ, Leslie KE, Godden S, Capel M, Santos JEP: The association of serum metabolites in the transition period with milk production and early-lactation reproductive performance. J Dairy Sci, 95, 1301-1309, 2012. DOI: 10.3168/jds.2011-4724
  • Carrier J, Stewart S, Godden S, Fetrow J, Rapnicki P: Evaluation and use of three cowside tests for detection of subclinical ketosis in early postpartum cows. J Dairy Sci, 87, 3725-3735, 2004. DOI:  10.3168/jds. S0022-0302(04)73511-0
  • Chapinal N, Carson M, Duffield TF, Capel M, Godden S, Overton M, Santos JEP, LeBlanc SJ: The association of serum metabolites with clinical disease during the transition period. J Dairy Sci, 94, 4897-4903, DOI: 10.3168/jds.2010-4075
  • Fahey J, Mee JF, O'Callaghan D: Can blood metabolites, body condition and milk production be used to predict reproductive performance in dairy cows? Ir Vet J, 54, 572-577, 2001.
  • Waters S, Morris DG, Diskin MG: The association between circulating metabolic hormones during the early postpartum period and subsequent fertility in dairy cow. Research Report RMIS, 5679, 145-148, 2006.
  • Falkenberg U, Haertel J, Rotter K, Iwersen M, Arndt G, Heuwieser W: Relationships between the concentration of Insulin-Like Growth Factor-1 in serum in dairy cows in early lactation and reproductive performance and milk yield. J Dairy Sci, 91, 3862-3868, 2008. DOI: 10.3168/ jds.2007-0887
  • Miettinen PV: Metabolic balance and reproductive performance in Finnish dairy cows. Zentralbl Veterinarmed, 37, 417-424, 1990. DOI: 1111/j.1439-0442.1990.tb00923.x
  • Hayhurst C, Sorensen MK, Royal MD, Lovendahl P: Metabolic regulation in Danish bull calves and the relationship to the fertility of their female offspring. J Dairy Sci, 90, 3909-3916, 2007. DOI: 10.3168/ jds.2006-731
  • Wathes DC, Bourne N, Cheng Z, Mann GE, Taylor VJ, Coffey MP: Multiple correlation analyses of metabolic and endocrine profiles with fertility in primiparous and multiparous cows. J Dairy Sci, 90, 1310-1325, DOI: 10.3168/jds.S0022-0302(07)71619-3
  • Burkhart M, Youngquist R, Spain J, Sampson J, Bader J, Vogel R, Lamberson W, Garverick A: NEFE and glucose levels in serum of periparturient dairy cows are indicative of pregnancy success at first service. J Dairy Sci, 88 (Suppl. 1): 299, 2005.
  • Butler WR, Smith RD: Interrelationships between energy balance and postpartum reproductive function in dairy cattle. J Dairy Sci, 72, 767, DOI: 10.3168/jds.S0022-0302(89)79169-4
  • Reist M, Koller A, Busato A, Kupfer U, Blum JW: First ovulation and ketone body status in the early postpartum period of dairy cows. Theriogenology, 54, 685-701, 2002. DOI: 10.1016/S0093-691X(00)00383-6
  • Friggens NC: Body lipid reserves and the reproductive cycle: Towards a better understanding. Livest Prod Sci, 83, 219-236, 2003. DOI: 10.1016/ S0301-6226(03)00111-8
  • Jorritsma R, Cesar ML, Hermans JT, Kruitwagen CLJJ, Vos PLAM, Kruip TAM: Effects of non-esterified fatty acids on bovine granulosa cells and developmental potential of oocytes in vitro. Anim Reprod Sci, 81, 225- , 2004. DOI: 10.1016/j.anireprosci.2003.10.005
  • Herdt TH: Ruminant adaptation to negative energy balance. Influences on the etiology of ketosis and fatty liver. Vet Clin North Am: Food Anim Pract, 16, 215-230, 2000. DOI: 10.1016/S0749-0720(15)30102-X
Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: 6
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
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