Selçuk GÜNEŞ, Mustafa ÇELİK, Burak OLGUN, İrem ÖZEN, Hüseyin Avni ULUSOY

Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi

Amaç: Malignite şüphesi nedeniyle yapılan nazofarenks punch biyopsi sonuçlarının değerlendirilmesi. Materyal ve Metod: Çalışmaya toplam 491 olgu (231 kadın 260 erkek; ortalama yaş 36.72±16.91 yıl, aralık 16-90 yıl) dahil edildi. Tüm olguların dosyaları, yaş, cinsiyet, biyopsi yapılma nedeni ve biyopsi sonuçları açısından retrospektif olarak değerlendirildi. Bulgular: Malignite şüphesi olan ve ayırıcı tanı amacıyla nazofarenks punch biyopsisi yapılan hastalardan 21’i (%4.2) nazofarenks karsinomu tanısı almıştır. Diğer olguların patolojik değerlendirme sonuçları; 454 benign patoloji (lenfoid hiperplazi, kronik lenfoid süreç, (Tornwald kisti) (%92.46), 12 yetersiz materyal (%2.44) ve 4 granülamatöz hastalık (%0.8) olarak saptanmıştır. Malignite saptanan olguların ortalama yaşları, patoloji sonucu benign olan olgulara göre istatistiksel olarak anlamlı düzeyde daha yüksektir (p=0.000). Malign ve benign olguların cinsiyet dağılımında istatistiksel olarak anlamlı farklılık saptanmamıştır. Sonuç: Nazofarenks kanseri şüphesinde, endoskopik muayenede yer kaplayıcı kitle olmasa da mukoza ve submukozayı içeren punch biyopsi uygulaması nazofarenks kanserinin erken tanı ve tedavisine imkan sağlayacaktır.

Anahtar Kelimeler:

nazofarenks; biyopsi; endoskopi; kanser; punch

Retrospective Analysis of Nasopharynx Punch Biopsy Results

Aim: Evaluation of nasopharyngeal punch biopsy results due to malignancy suspicion.Material and Method: In total, 491 patients (231 females 260 males; average age 36.72± 16.91 years; range 16 –90 years) were included in the present study. All patients files were evaluated in terms of age, gender, the reason and the results of biopsy.Results: Nasopharyngeal carcinoma was diagnosed in 21 patients (4.2%) as a result of nasopharyngeal punch biopsies performed due to malignancy suspicion and exclusion. Results of pathological evaluation of other patients; 454 benign pathologies (lymphoid hyperplasia, chronic lymphoid process, Tornwald cyst) (92.05%), 12 insufficient material (2.44%) and 4 granulomatous diseases (0.8%), respectively. The mean age of patients with malignancy was statistically significantly higher than those with benign pathology (p = 0.000). There was no statistically significant difference in the gender distribution of malignant and benign cases (p = 0.077). Conclusion: Taking punch biopsies containing mucosa and submucosa will provide the early diagnosis and treatment of nasopharyngeal carcinoma, in spite of the absence of a mass on endoscopic examination.

Keywords:

nasopharynx, biopsy, endoscopy cancer,

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