Levotiroksin Sodyum Tedavisi Alan Hipotiroid Hastalarda 25-Hidroksi-Vitamin D Düzeylerinin Değerlendirilmesi
Amaç: Bu çalışma ile levotiroksin sodyum (LT4) tedavisi alan ve ötiroid seyreden hipotiroid hastalarda 25-Hidroksi-Vitamin D (25 (OH) D) düzeyinin değerlendirilmesi amaçlandı. Materyal ve Metot: Çalışmaya İç Hastalıkları polikliniğinde LT4 tedavisi alan ve ötiroid seyreden hipotiroidili 116 hasta ile, kontrol grubu olarak benzer yaş ortalamasında ve cinsiyette hipotiroid olmayan 110 hasta alınmıştır. Hastalar yaş, cinsiyet, aldıkları LT4 ilaç dozları ilserbest T4, TSH, 25 (OH) D, BUN, Kreatinin, Kalsiyum (Ca), Fosfor (P), Albümin değerleri açısından kaydedildi. Gruplar arasında anlamlı fark olup olmadığı araştırıldı. Bulgular: Çalışmada LT4 tedavisi alan ve ötiroid seyreden hipotiroid tanılı hastalarda, kontrol grubu hastalarına göre 25 (OH) D düzeyi, anlamlı olarak düşük bulundu (p<0,001). Hasta grubunda 25 (OH) D düzeyleri ile hastaların aldıkları LT4 ilaç dozları arasında anlamlı bir ilişki yoktu (r=0,060 p=0,52). Kadınlar ve erkekler arasında 25 (OH) D düzeyleri açısından anlamlı bir ilişki yoktu (p=0,75). Sonuç: LT4 tedavisi alan ve ötiroid seyreden hipotiroid hastalarda, 25 (OH) D düzeyinin düşük bulunması, hipotiroidinin etiyolojisinde düşük vitamin D düzeyinin rolünün olabileceği, ayrıca düşük vitamin D düzeyi olan hipotiroidili hastalara LT4 tedavisine ilave olarak aktif vitamin D verilmesinin faydalı olabileceği sonucuna varıldı.
Evaluation of 25-Hydroxy-Vitamin D Levels in Hypothyroid Patients Receiving Levothyroxine Sodium Therapy
Aim: It was aimed to evaluate 25-hydroxy-vitamin D (25 (OH) D) levels in hypothyroid patients with levothyroxine sodium (LT4) therapy and euthyroidism. Material and Method: 116 patients with hypothyroidism with LT4 treatment and euthyroidism in the Internal Medicine Policlinic, as control group, 110 patients with similar age and sex without hypothyroidism were enrolled to study. Patients were recorded in terms of age, sex, LT4 drug doses and free T4, TSH, 25 (OH) D, BUN, Creatinine, Calcium (Ca), Phosphorus (P), Albumin values. There was a significant difference between the groups. Results: In study, 25 (OH) D level was significantly lower in patients with hypothyroid patients receiving LT4 therapy and euthyroidism than in control group (p<0.001). In the patient group there was no significant relationship between the 25 (OH) D levels and the LT4 drug doses received by the patients (r=0.060 p=0.52). There was no relationship in the 25 (OH) D levels between the women and the men (p=0.75). Conclusion: It was concluded that 25 (OH) D levels may be lower in hypothyroid patients treated with LT4 and that low vitamin D levels may be involved in the etiology of hypothyroidism and that active vitamin D supplementation in addition to LT4 therapy with hypothyroidism may be beneficial.
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