Sarra SIBOUS, Said BOUKHRIS, Rachida GHAILANE, Nouzha HABBADI, Amina HASSIKOU, Abdelaziz SOUIZI

EASY SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN -2-(1H)-ONES USING PHOSPHATE FERTILIZERS MAP, DAP AND TSP AS EFFICIENT CATALYSTS

A simple, efficient and green procedure has been developed for the synthesis of dihydropyrimidinones (Products of Biginelli) using phosphate fertilizers (mono-ammonium phosphate (MAP), di-ammonium phosphate (DAP) and triple super phosphate (TSP)) as catalyst. The one-step reaction involved the three compounds, which are registered aromatic aldehydes, dicarbonyl compounds and the urea/thiourea. This new method provides some advantages such as obtaining excellent yields (98%), as well as the short duration of the reaction, which may attain 2 min. These catalytic heterogeneous systems present also the advantage of being easily recycled.

Keywords:

Heterogeneous catalysts, MAP, DAP, TSP, 3, 4-dihydropyrimidin-2(1H)-ones,

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Journal of the Turkish Chemical Society Section A: Chemistry-Cover

Başlangıç: 2014
Yayıncı: Türkiye Kimya Derneği

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