This review covers a summary of analytical applications of hydrazone derivatives in a systematic manner (1961-2021), which will help researchers in the design and development of hydrazone derivatives as potential candidates in medicinal, pharmaceutical, catalytic, and analytical chemistry, especially in the separation, identification, and detection of several metal ions, anions, organic molecules, and water in various real and synthetic samples. In addition to these, hydrazone derivatives may be used as light emitting diodes, for synthesis of DSSC, nanoparticles and polymers, as corrosion inhibitors, as dyes, etc. This review does not include all papers in this field, but it does synthesize all significant works on the subject.