Adnan BARUTÇU, Ferda ÖZLÜ, Hacer YAPICIOĞLU, Sevcan ALINÇ ERDEM, Ramazan ÖZDEMİR

Yenidoğan döneminde olağandışı birliktelik: Taşiaritmi ve hipotiroidizm

Konjenital hipotiroidizm yenidoğanlarda önemli bir sorundur. Şiddetli hipotiroidizm vakalarında çeşitli kardiyak anormallikler tanımlanmıştır. Hipotiroidizm yaygın olarak sinüs bradikardisi, düşük QRS kompleksleri, uzun QT aralığı ve iletim blokları ile ilişkilidir, ancak nadiren aritmilere neden olabilir. Supraventriküler aritmiler hipertiroidizmin sıradan özellikleri olmasına rağmen; Bu çalışmanın amacı supraventriküler taşikardi ve hipotiroidizm arasındaki olası etyolojik bağın altını çizmektir. Literatürde hipotiroidizm ve taşiaritmi birlikteliği olan birkaç erişkin olgu daha önce bildirilmiş olmasına rağmen, bilgimize göre yenidoğanlarda bildirilen vakalar sadece bunlardır.

Anahtar Kelimeler:

Yenidoğan, Hipotiroidizm, Taşikardi

Unusual concomitance during the neonatal period: Tachyarrhythmia and hypothyroidism

Congenital hypothyroidism is a significant issue in neonates. A variety of cardiac abnormalities have been described in cases of severe hypothyroidism. It is commonly associated with sinus bradycardia, low QRS complexes, prolonged QT interval and conduction blocks but may rarely cause arrhythmias. Although supraventricular arrhythmias are ordinary features of hyperthyroidism, the aim of this report is to underline the possible etiological link between supraventricular tachycardia and hypothyroidism. Although a few adult cases with hypothyroidism and tachyarrhythmia have been previously reported in the literature, to our knowledge, these are the only neonatal cases reported.

Keywords:

Neonate, Hypothyroidism, Tachycardia,

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1. Raymond J, La Franchi SH. Fetal and neonatal thyroid function: review and summary of significant new findings. Curr Opin Endocrinol Diabetes Obes. 2010;17:1-7. doi: 10.1097/med.0b013e328333b0b2
2. Polikar R, Burger AG, Scherrer U. The thyroid and the heart. Circulation. 1993;87:1435–41. doi: 10.1161/01.cir.87.5.1435
3. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001;344:501–9. doi: 10.1056/NEJM200102153440707
4. Park MK. Cardiac arrhytmias. In: Park MK. Pediatric Cardiology for Practitioners. 5th ed. Philedelphia, USA: Mosby Elsevier Pres, 2008: 417-444.
5. Kantoch MJ. Supraventricular tachycardia in children Indian J Pediatr. 2005;72:609-19. doi: 10.1007/bf02724188
6. Gilljam T, Jaeggi E, Gow RM. Neonatal supraventricular tachycardia: outcomes over a 27-year period at a single institution. Acta Paediatr. 2008;97:1035-9. doi: 10.1111/j.1651-2227.2008.00823.x
7. Olarescu C, Ghervan C, Hazi G, Duncea I. New clinical feature in hypothyroidism: paroxysmal supraventricular tachycardia: case report. 25-29 April 2009, European Congress of Endocrinology 2009 Istanbul, Turkey.
8. Schenck JB, Rizvi AA, Lin T. Severe primary hypothyroidism manifesting with torsades de pointes. Am J Med Sci. 2006;331:154-6. doi: 10.1097/00000441-200603000-00008
9. Liu CR, Li LY, Shi F, Zang XY, Liu YM, Sun Y, et al. Effects of hyper- and hypothyroid on expression of thyroid hormone receptor mRNA in rat myocardium. J Endocrinol. 2007;195:429-38. doi: 10.1677/JOE-07-0253
10. Mao SS, Zhao ZY, Jiang GP. Influence of congenital hypothyroidism on left ventricular function of neonates. Zhonghua Er Ke Za Zhi. 2004;42:507-10.
11. Yang H, Nyby MD, Ao Y, Chen A, Adelson DW, Smutko V, et al. Role of brainstem thyrotropin-releasing hormone-triggered sympathetic overactivation in cardiovascular mortality in type 2 diabetic Goto-Kakizaki rats. Hypertens Res. 2012;35:157-65. doi: 10.1038/hr.2011.154
12. Shojaie M, Eshraghian A. Primary hypothyroidism presenting with Torsades de pointes type tachycardia: a case report Cases J. 2008;1:298. doi: 10.1186/1757-1626-1-298
13. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001;344:501–9. doi: 10.1056/NEJM200102153440707