İsmail BIYIK, Mehmet Musa ASLAN, Fatih KESKİN

Missed abortus ile platelet indekslerinin ilişkisi

Amaç: Klinik olarak tanı almış gebeliklerin %15’i missed abortus ile sonuçlanmaktadır. Missed abortusun etyolojisi kesin olarak bilinmemektedir. Literatürde sınırlı sayıda çalışmada ortalama platelet hacmi (MPV), platelet dağılım genişliği (PDW), plateletrikt (PCT)’in missed abortusta arttığı bildirilmiştir. Çalışmalardaki olgu sayısı az ve sonuçları tutarsızdır. Literatürde, missed abortusta tüm platelet indekslerini değerlendiren bir çalışma bulunmamaktadır. Bu çalışma missed abortusta tüm platelet indekslerini değerlendiren literatürdeki en geniş seridir.Yöntemler: Bu retrospektif olgu-kontrol çalışmasında, missed abortus tanısı alan hastaların tam kan sayımı parametreleri karşılaştırıldı. Çalışmada toplam 500 olgunun missed abortus tanısı alan 228’i çalışma grubu, 272 sağlıklı gebe olanı kontrol grubu belirlendi. Çalışmaya 18-45 yaş aralığında, 6-14 gebelik haftasındaki tekil gebeler dahil edildi.Bulgular: Missed abortus grubunda PDW değeri kontrol grubuna göre yüksek bulunurken (P=0,007); MPV ve PCT değerleri düşük bulundu (sırasıyla P<0,001 ve P=0,008).Sonuç: Missed abortusta platelet indeksi parametreleri tutarsızdır.

Anahtar Kelimeler:

Missed abortus, Platelet indeksleri, Ortalama platelet hacmi, Platelet dağılım genişliği

Association between platelet indices and missed abortion

Aim: The incidence of missed abortion is around 15% of clinically diagnosed pregnancies, and the etiology is uncertain. Limited studies in the literature report increased platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT). The number of cases in these studies is low and results are inconsistent. There is no study that investigates all platelet indices. This study has the largest series in the literature and investigates all platelet indices in missed abortion. Methods: In this retrospective case-control study, the complete blood count parameters of patients who were diagnosed with missed abortion were examined. Among 500 cases, 228 women with missed abortion constituted the study group, and 272 healthy pregnant women constituted the control group. Women who were 18–45 years of age and 6–14 weeks of gestational age were included. Results: In the missed abortion group, PDW value was higher (P=0.007), while platelet MPV and PCT values were lower (respectively P<0.001 and P=0.008) than the control group.Conclusion: Platelet indices parameters in missed abortion are inconsistent.

Keywords:

Missed abortion, Platelet indices, Mean platelet volume, Platelet distribution width,

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