Zeynep Gizem Kaya İSLAMOĞLU, Abdullah DEMİRBAŞ

Diskoid lupus eritematozus hastalarında ortalama trombosit hacmi ve trombosit dağılım genişliği seviyeleri: Bir olgu-kontrol çalışması

Amaç: Trombositler (PLT) inflamatuar reaksiyonlarda ve immün yanıtlarda önemli bir rol oynar. Bu çalışma, inflamasyonla karakterize diskoid lupus eritematozus (DLE) hastalarında PLT ve PLT parametrelerini değerlendirmeyi amaçlamaktadır.Yöntemler: Bu vaka kontrol çalışmasında, 60 DLE hastası ve 65 sağlıklı kontrol grubu olmak üzere toplam 125 katılımcı seçilmiştir. PLT, trombosit dağılım genişliği (PDW), ortalama trombosit hacmi (MPV), trombosit (PCT), nötrofillerin lenfositlere (NLR) oranı ve trombositlerin lenfositlere (PLR) oranı retrospektif olarak her iki grupta da incelenmiştir.Bulgular: Hasta grubunun yaş ortalaması 47,30 (15,14), kontrol grubunun yaş ortalaması 38,08 (13,33) idi. DLE hastalarında ve sağlıklı kontrollerde PLT, PDW, MPV, PCT, NLR ve PLR düzeyleri arasında istatistiksel olarak anlamlı bir fark yoktu (sırasıyla P=0,365, P=0,988, P=0,160, P=0,851, P=0,898 ve P=0,887).Sonuç: Bildiğimiz kadarıyla DLE'li hastalarda hem PLT, PDW, PCT, NLR, PLR, hem de MPV hakkında çalışma yoktur. Çalışmamızda DLE grubunda anlamlı bir fark bulamadık. PLT parametreleri, inflamatuar hastalıklarda inflamasyon seviyelerini tanımlamak için kullanılabilecek düşük maliyetli testlerdir. Bu konuyla ilgili ileriye dönük çalışmalar bu çalışmaya katkıda bulunacaktır.

Anahtar Kelimeler:

Trombositler, Ortalama trombosit hacmi, Trombosit dağılım genişliği, Diskoid lupus eritematozus, İnflamasyon

Mean platelet volume and platelet distribution width levels in discoid lupus erythematosus patients: A case-control study

Aim: Platelets (PLT) play an important role in inflammatory reactions and immune responses. This study aims to evaluate PLT and PLT parameters in patients with discoid lupus erythematosus (DLE), which is characterized by inflammation.Methods: In this case-control study, a total of 125 participants, consisting of 60 DLE patients and 65 healthy controls, were selected to participate. PLT, platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), the ratio of neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes (PLR) were studied retrospectively in both groups.Results: The mean age of the patient group was 47.30 (15.14) years, and the mean age of the control group was 38.08 (13.33) years. There were no statistically significant differences between the PLT, PDW, MPV, PCT, NLR and PLR levels in DLE patients and healthy controls (P=0.365, P=0.988, P=0.160, P=0.851, P=0.898 and P=0.887, respectively).Conclusion: To the best of our knowledge, there are no reports on both PLT, PDW, PCT, NLR, PLR and MPV in patients with DLE. We did not find a significant difference in the DLE group. PLT parameters are low-cost tests that can be used to define inflammation levels in inflammatory diseases. Further prospective studies on this subject will contribute to this work.

Keywords:

Platelets, Mean platelet volume, Platelet distribution width, Discoid lupus erythematosus, Inflammation,

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