Karaciğer nakli alıcılarında latent tüberküloz enfeksiyonu proflaksisi

Amaç: İmmünsüpresif ilaçlar karaciğer nakli alıcısını latent tüberküloz enfeksiyonlarının reaktivasyonuna yatkınlaştırır. Bu hastalara verilen profilaktik tedaviler, reaktivasyonun önlenmesi için çok önemlidir. Bu çalışmanın amacı, karaciğer nakli alıcılarında latent tüberküloz enfeksiyonlarının profilaksisini değerlendirmektir.Yöntemler: Retrospektif bir kohort çalışması tasarladık. Karaciğer nakli alıcılarını Aralık 2014 - Aralık 2017 tarihleri arasında T Spot ve profilaktik tedavi sonuçları ile inceledik.Bulgular: 143 alıcı arasında, 21 (%14,7) vakada pozitif T Spot sonucu tespit edildi. Yirmi bir hastaya İsoniazid profilaksisi yapıldı ve 48 aylık takipte tüberkülozun herhangi bir reaktivasyonu tespit edilmedi.Sonuç: Isoniazid, karaciğer nakli alıcılarında latent tüberküloz enfeksiyonunun profilaktik tedavisinde başarılı görünmektedir.

Anahtar Kelimeler:

Karaciğer nakli, Latent tüberküloz enfeksiyonu, Proflaksi

Prophylaxis for latent tuberculosis infection in liver transplant recipients

Aim: Immunosuppressive drugs predispose the liver transplant recipient to reactivation of latent tuberculosis infections. Prophylactic therapies given to these patients are very important for prevention of reactivation. The aim of this study was to evaluate the prophylaxis of latent tuberculosis infections in liver transplant recipients.Methods: We designed a retrospective cohort study. We examined liver transplant recipients Between December 2014 and December 2017 with results of T Spot and prophylactic treatment.Results: Among 143 recipients, positive T Spot results were detected in 21 (14.7%) cases. Twenty one patients received Isoniazid prophylaxis and no reactivation of tuberculosis was detected during follow-up of 48 months.Conclusion: Isoniazid appears to be successful in prophylactic treatment of latent tuberculosis infection in liver transplant recipients.

Keywords:

Liver transplantation, Latent tuberculosis infections, Prophylaxis,

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