Yonca YILMAZ ÜRÜN, Mahmut ÖZDEMİR, Ramazan ASOĞLU, Namık YİĞİT

Kalp yetersizliği olan hastalarda galektin-3'ün değerlendirilmesi ve NT-proBNP düzeyleri ile ilişkisi: Vaka-kontrol çalışması

Amaç: Kardiyak fibroz kardiyak remodelingde patolojik bir durumdur ve kalp hastalıkları ile ilişkilidir. Bu çalışmanın amacı galaktin-3'ün kalp yetmezliği (KY) olan hastalarda N-terminal pro B tipi natriüretik peptid (NT-pro-BNP) düzeyleri ile ilişkisini araştırmaktır.Yöntemler: Çalışmaya KY tanısı olan toplam 50 hasta (hasta grubu) ve ejeksiyon fraksiyonu normal olan 30 birey (kontrol grubu) dahil edildi. Tüm bireylerde serum galektin‐3 ve plazma NT-pro-BNP düzeyleri ölçüldü. Bireylerin demografik ve klinik özellikleri kaydedildi. Galaktin-3 ve NT-pro-BNP düzeyleri gruplar arasında karşılaştırıldı.Bulgular: KY olan hastalarda galaktin-3 ve NT-pro-BNP düzeyleri kontrol grubundan (37.5 (18.0-80.0), 12.0 (8.0-14.0), P<0.001; 467.0 (1157.5-5107.2), 50.0 (35.0-102.0) P<0.001, sırasıyla) anlamlı derecede yüksek bulundu.. Galaktin-3, KY hastalarında serum glukoz, kreatin, sol atriyal çap, ejeksiyon fraksiyonu ve NT-pro-BNP düzeyleri ile korele olarak bulundu. NT-pro-BNP ve Galaktin-3 düzeyleri arasında pozitif ve anlamlı bir ilişki vardı (r=0.742 P=0.001). Ayrıca, ejeksiyon fraksiyonu ile Galaktin-3 seviyeleri arasında negatif ve anlamlı bir korelasyon vardı (r=-0.556, P=0.001).Sonuç: Sonuç olarak, bu çalışma, sistolik HF hastalarında galektin-3 ve NT-pro-BNP düzeylerinin anlamlı şekilde daha yüksek olduğunu göstermektedir. Galektin-3, NT-pro-BNP ile pozitif ve anlamlı, ejeksiyon fraksiyonu ile negatif korelasyon gösterdi.

Anahtar Kelimeler:

Galaktin-3, NT-pro-BNP, NT-pro-BNP, Kalp yetmezliği, Ejeksiyon fraksiyonu

Evaluation of galectin-3 in patients with heart failure and its relationship with NT-proBNP levels: A case-control study

Background: Cardiac fibrosis is a pathological phenomenon in cardiac remodelling and it is associated with heart diseases. The aim of this study was to investigate the relationship of galactin-3 with N-terminal pro B-type natriuretic peptide (NT-pro-BNP) levels in patients with heart failure (HF). Material and Method: A total of 50 patients with HF and 30 patients with normal ejection fraction were enrolled into this study. Serum galectin‐3 levels and plasma NT-pro-BNP were measured in all subjects. Demographic and clinical characteristics of the patients were recorded. The galactin-3 and NT-pro-BNP levels were compared between the groups. Results: Patients with HF had significantly higher galactin-3 and NT-pro-BNP levels than control patients (37.50 (18.00-80.00) versus 12.00 (8.00-14.00), P<0.001; 467.00 (1157.50-5107.25) versus 50.00 (35.00-102.00) P<0.001, respectively). galactin-3 was correlated with serum glucose, creatine, left atrial diameter, ejection fraction and NT-pro-BNP in the HF patients. There was a positive and significant correlation between the NT-pro-BNP and Galactine-3 levels (r=0.742 P=0.001). In addition, there was an inverse and significant correlation between the ejection fraction and Galactine-3 levels (r=-0.556 P=0.001). Conclusion: This study demonstrated an association between galactin-3 and NT-pro-BNP levels. We found that galactin-3 and NT-pro-BNP levels was significantly higher in patients with HF. Our study also showed that galactin-3 was strongly correlated with NT-pro-BNP levels.

Keywords:

Galectin-3, NT-pro-BNP, Heart failure, Ejection fraction,

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