Hepatosellüler karsinomda canlı vericili karaciğer nakli: Tek merkez deneyimi

Amaç: Hepatosellür karsinom ( HCC ) karaciğerin en sık görülen primer solid tümörüdür. Hepatit B virus (HBV) enfeksiyonları, hepatit C virus ( HCV ) enfeksiyonları veya alkolizm zemininde de görülebilir. Bu çalışmanın amacı, HCC nedeniyle canlı vericili karaciğer nakli yapılan hastaların değerlendirilmesidir.Yöntemler: Retrospektif kohort çalışma planlandı. Nisan 2014 – Aralık 2017 tarihleri arasında Medipol Üniversitesi Tıp Fakültesi, Organ Nakli Merkezi'nde HCC nedeniyle canlı vericili karaciğer nakli yapılan 38 hasta değerlendirildi. Bulgular: Ortalama yaş 58,0 (9,9) (20-74) yıldı; 38 kişiden 31'i (%81,6) erkekti. Ortalama MELD skoru 14,2 (8–32) idi. Milan kriterleri dışında (P=0,003), kötü farklılaşmış ve kolanjiokarsinom tümör bileşeni (P=0,003), olan hepatosellüler karsinomda canlı vericili karaciğer naklinde daha kötü görünmektedir.Sonuçlar: Bu çalışmada Milan dışı, az differansiye ve kolanjiokarsinom komponenti olan tümörlerin daha kötü olduğu görünmektedir.

Anahtar Kelimeler:

Hepatosellüler karsinom, Canlı vericili karaciğer nakli

Living donor liver transplantation in hepatocellular carcinoma: A single-center experiences

Aim: Hepatocellular carcinoma (HCC) is the most common primary solid tumor of the liver. Hepatitis B virus (HBV) infections, Hepatitis C virus (HCV) infections and at alcoholism can be seen. The aim of this study was to evaluate living donor liver transplantation in hepatocellular carcinoma.Methods: This is a retrospective cohort study. Between April 2014 and December 2017 at Medipol University Medical Faculty Hospital Organ Transplantation Department, 38 patients in living donor liver transplantation for HCC were evaluated.Results: The mean patient age was 58.0 (9.9) (20–74) years; 31 (81.6%) of the 38 were male. The mean MELD score was 14.2 (8–32). Outside Milan criteria (P=0.003), poorly differentiated and cholangiocarcinoma tumor component (P=0.003) appears to be worse in living donor liver transplantation in hepatocellular carcinoma.Conclusions: In this study, outside Milan criteria, poorly differentiated and cholangiocarcinoma tumor component appears to be worse in living donor liver transplantation in hepatocellular carcinoma.

Keywords:

Hepatocellular carcinoma, Living donor liver transplantation,

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