Abdelouhab EL MAROUNİ, Karam AZİZ, İmane TOGHRAİ, Khalid MAZAZ, Karim IBN MAJDOUB

Ekstraovaryen granulosa hücreli tümör: Olgu sunumu

Overin granuloza hücreli tümörü (GCT), tüm over neoplazmalarının %2-5'ini oluşturan nadir bir tümördür. Tedaviden birkaç yıl sonra yeniden ortaya çıkabilir veya metastaz yapabilir. Sık olmamakla birlikte, embriyonik genital katlantı üzerindeki ektopik gonadal dokudan köken alarak, ekstra-overyen bir bölgede de görülebilir. Burada bir ekstraovaryen granüloza tümörünü, klinik, terapötik yönleri ve kendi yaklaşımımızla birlikte sunuyoruz.

Anahtar Kelimeler:

Ekstraovaryan, Granulosa hücreli tümör, Histolojik tanı

Extraovarian granulosa cell tumor: A case report

Granulosa cell tumor (GCT) of the ovary is a rare tumor representing 2 to 5% of all ovarian neoplasms. It can reproduce or metastasize several years after the initial treatment. In rare cases, CGT can develop on an extra-ovarian site, which is thought to originate from ectopic gonadal tissue along the embryonic genital ridge. We herein present a case of extraovarian granulosa tumor, the clinical and therapeutic aspects, and our approach.

Keywords:

Extraovarian, Granulosa cell tumor, Histological diagnosis,

PDF

___

1. Schumer ST, Cannistra SA. Granulosa cell tumour of the ovary. J Clin Oncol. 2003;21:1180-9.
2. Serov SF, Scully RE, Sobin LH: International Histological Classification of Tumours, No. 9. Histological Typing of Ovarian Tumors. Geneva, World Health Organization, 1973
3. Kim SH, Park HJ, Linton JA, Shin DH, Yang WI, Chung WY, et al. Extraovarian granulosa cell tumour. Yonsei Med J. 2001;42:360-3.
4. Cronjι HS, Niemand I, Bam RH, Woodruff JD. Review of the ¬granulosa-theca cell tumors from the emil Novak ovarian tumor registry. Am J Obstet Gynecol. 1999;180:323-7.
5. Reddy DB, Rao DB, Sarojini JS. Extraovarian granulosa cell tumour. J Indian Med Assoc. 1963;41:254-7.
6. Sakai Y. Granulosa cell tumor arising in the wall of müllerian cyst of the broad ligament: Report of a case and immunohistochemical study. Arch Gynecol Obstet. 2007;275:145-8.
7. Motta PM, Makabe S. Germ cells in the ovarian surface during fetal development in humans. J Submicrosc Cytol 1986;18:271-90.
8. Lal A, Bourtsos EP, Nayar R, DeFrias DV. Cytologic features of granulosa cell tumours in fluids and fine needle aspiration specimens. Acta Cytol. 2004;48:315-20.
9. Stenwig JT, Hazekamp JT, Beecham JB. Granulosa cell tumours of the ovary: A clinico-pathological study of 118 cases with long term follow-up. Gynecol Oncol. 1979;7:136-52.
10. Lappφhn RE, Burger HG, Bouma J, Bangah M, Krans M, de Bruijn HW. Inhibin as a marker for granulosa-cell tumors. N Engl J Med. 1989;321:790-3.