___

• Abdul-Hammed, M., Adedotun, I. O., Olajide, M., Irabor, C. O., Afolabi, T. I., Gbadebo, I. O., … Ramasami, P. (2021). Virtual screening, ADMET profiling, PASS prediction, and bioactivity studies of potential inhibitory roles of alkaloids, phytosterols, and flavonoids against COVID-19 main protease (M-pro). Natural Product Research.
• Agrawal, P K, Agrawal, C., & Blunden, G. (2021). Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19. Natural Product Communications, 16(10).
• Agrawal, Pawan K., Agrawal, C., & Blunden, G. (2021). Rutin: A Potential Antiviral for Repurposing as a SARS-CoV-2 Main Protease (Mpro) Inhibitor. Natural Product Communications, 16(4). https://doi.org/10.1177/1934578X21991723
• Alhadrami, H. A., Sayed, A. M., Hassan, H. M., Youssif, K. A., Gaber, Y., Moatasim, Y., … Gamaleldin, N. M. (2021). Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics. Antibiotics-Basel, 10(5).
• Ali, A. M., & Kunugi, H. (2021). Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies. Molecules, 26(5).
• Allam, A. E., Assaf, H. K., Hassan, H. A., Shimizu, K., & Elshaier, Y. A. M. M. (2020). Anin silicoperception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19. Rsc Advances, 10(50), 29983–29998.
• Babaeekhou, L., Ghane, M., & Abbas-Mohammadi, M. (2021). In silico targeting SARS-CoV-2 spike protein and main protease by biochemical compounds. Biologia, 76(11), 3547–3565.
• Batool, F., Mughal, E. U., Zia, K., Sadiq, A., Naeem, N., Javid, A., … Saeed, M. (2020). Synthetic flavonoids as potential antiviral agents against SARS-CoV-2 main protease. Journal of Biomolecular Structure & Dynamics.
• Bhati, S., Kaushik, V., & Singh, J. (2021). Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19. Journal of Molecular Structure, 1237.
• Bhowmik, D., Nandi, R., Prakash, A., & Kumar, D. (2021). Evaluation of flavonoids as 2019-nCoV cell entry inhibitor through molecular docking and pharmacological analysis. Heliyon, 7(3).
• Biagioli, M., Marchiano, S., Roselli, R., Di Giorgio, C., Bellini, R., Bordoni, M., … Fiorucci, S. (2021). Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction. Biochemical Pharmacology, 188.
• Bolelli, K., Ertan-Bolelli, T., Unsalan, O., & Altunayar-Unsalan, C. (2021). Fenoterol and dobutamine as SARS-CoV-2 main protease inhibitors: A virtual screening study. Journal of Molecular Structure, 1228(xxxx), 129449. https://doi.org/10.1016/j.molstruc.2020.129449
• Chan, J. F. W., Yuan, S., Kok, K. H., To, K. K. W., Chu, H., Yang, J., … Yuen, K. Y. (2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The Lancet, 395(10223), 514–523. https://doi.org/10.1016/S0140-6736(20)30154-9
• Chapman, R. L., & Andurkar, S. V. (2021). A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19. Medicinal Chemistry Research.
• Chen, C. N., Lin, C. P. C., Huang, K. K., Chen, W. C., Hsieh, H. P., Liang, P. H., & Hsu, J. T. A. (2005). Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′- digallate (TF3). Evidence-Based Complementary and Alternative Medicine, 2(2), 209–215. https://doi.org/10.1093/ecam/neh081
• Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., … Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet, 395(10223), 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7
• da Silva, F. M. A., da Silva, K. P. A., de Oliveira, L. P. M., Costa, E. V, Koolen, H. H. F., Pinheiro, M. L. B., … de Souza, A. D. L. (2020). Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp). Memorias Do Instituto Oswaldo Cruz, 115.
• Dallakyan, S., & Olson, A. J. (2015). Small-molecule library screening by docking with PyRx. Methods in Molecular Biology, 1263(January 2015), 243–250. https://doi.org/10.1007/978-1-4939-2269-7_19
• Das, P., Majumder, R., Mandal, M., & Basak, P. (2021). In-Silico approach for identification of effective and stable inhibitors for COVID-19 main protease (M-pro) from flavonoid based phytochemical constituents ofCalendula officinalis. Journal of Biomolecular Structure & Dynamics, 39(16), 6265–6280.
• Dubey, K., & Dubey, R. (2020). Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor. Biomedical Journal, 43(4), 363–367. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233213/pdf/main.pdf
• Dubey, R., & Dubey, K. (2021). Molecular Docking Studies of Bioactive Nicotiflorin against 6W63 Novel Coronavirus 2019 (COVID-19). Combinatorial Chemistry & High Throughput Screening, 24(6), 874–878.
• Ebada, S. S., Al-Jawabri, N. A., Youssef, F. S., El-Kashef, D. H., Knedel, T. O., Albohy, A., … Proksch, P. (2020). Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure-activity relationships, molecular modeling and impact on its folk medicinal uses. Rsc Advances, 10(62), 38128–38141.
• Fadaka, A. O., Sibuyi, N. R. S., Martin, D. R., Klein, A., Madiehe, A., & Meyer, M. (2021). Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease. International Journal of Molecular Sciences, 22(17).
• Fakhar, Z., Faramarzi, B., Pacifico, S., & Faramarzi, S. (2021). Anthocyanin derivatives as potent inhibitors of SARS-CoV-2 main protease: An in-silico perspective of therapeutic targets against COVID-19 pandemic. Journal of Biomolecular Structure & Dynamics, 39(16), 6171–6183.
• Fayed, M. A. A., El-Behairy, M. F., Abdallah, I. A., Abdel-Bar, H. M., Elimam, H., Mostafa, A., … Elshaier, Y. A. M. M. (2021). Structure- and Ligand-Based in silico Studies towards the Repurposing of Marine Bioactive Compounds to Target SARS-CoV-2. Arabian Journal of Chemistry, 14(4).
• Glaab, E., Manoharan, G. B., & Abankwa, D. (2021). Pharmacophore Model for SARS-CoV-2 3CLpro Small-Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors. Journal of Chemical Information and Modeling, 61(8), 4082–4096. Retrieved from https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00258
• Gogoi, N., Chowdhury, P., Goswami, A. K., Das, A., Chetia, D., & Gogoi, B. (2021). Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease. Molecular Diversity, 25(3), 1745–1759. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685905/pdf/11030_2020_Article_10150.pdf
• Gomez, C. R., Espinoza, I., Faruke, F. S., Hasan, M., Rahman, K. M., Walker, L. A., & Muhammad, I. (2021). Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach. Molecules, 26(4).
• Goris, T., Perez-Valero, A., Martinez, I., Yi, D., Fernandez-Calleja, L., San Leon, D., … Nogales, J. (2021). Repositioning microbial biotechnology against COVID-19: the case of microbial production of flavonoids. Microbial Biotechnology, 14(1), 94–110. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675739/pdf/MBT2-14-94.pdf
• Gorla, U. S., Rao, G. K., Kulandaivelu, U. S., Alavala, R. R., & Panda, S. P. (2021). Lead Finding from Selected Flavonoids with Antiviral (SARS-CoV-2) Potentials Against COVID-19: An In-silico Evaluation. Combinatorial Chemistry & High Throughput Screening, 24(6), 879–890.
• Guler, H. I., Sal, F. A. Y., Can, Z., Kara, Y., Yildiz, O., Belduz, A. O., … Kolayli, S. (2021). Targeting CoV-2 spike RBD and ACE-2 interaction with flavonoids of Anatolian propolis by in silico and in vitro studies in terms of possible COVID-19 therapeutics. Turkish Journal of Biology, 45(4), 530–548. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576337/pdf/turkjbio-45-530.pdf
• Guler, H. I., Tatar, G., Yildiz, O., Belduz, A. O., & Kolayli, S. (2021). Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study. Archives of Microbiology, 203(6), 3557–3564. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098016/pdf/203_2021_Article_2351.pdf
• Gurung, A. B., Ali, M. A., Lee, J., Abul Farah, M., Al-Anazi, K. M., & Al-Hemaid, F. (2021). Identification of SARS-CoV-2 inhibitors from extracts of Houttuynia cordata Thunb. Saudi Journal of Biological Sciences, 28(12), 7517–7527.
• Hassan, A. R., Sanad, I. M., Allam, A. E., Abouelela, M. E., Sayed, A. M., Emam, S. S., … Shimizu, K. (2021). Chemical constituents from Limonium tubiflorum and their in silico evaluation as potential antiviral agents against SARS-CoV-2. Rsc Advances, 11(51), 32346–32357.
• Hiremath, S., Kumar, H. D. V, Nandan, M., Mantesh, M., Shankarappa, K. S., Venkataravanappa, V., … Reddy, C. N. L. (2021). In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2. 3 Biotech, 11(2).
• Hu, X. P., Cai, X., Song, X., Li, C. Y., Zhao, J., Luo, W. L., … He, Z. D. (2020). Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptor. Future Virology, 15(6), 359–368.
• Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
• Huang, F., Zhang, C., Liu, Q., Zhao, Y., Zhang, Y., Qin, Y., … Jiang, C. (2020). Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury. PLoS Pathogens, 16(3), 1–16. https://doi.org/10.1371/journal.ppat.1008341
• Ibrahim, M. A. A., Abdelrahman, A. H. M., Atia, M. A. M., Mohamed, T. A., Moustafa, M. F., Hakami, A. R., … Hegazy, M. E. F. (2021). Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition. Marine Drugs, 19(7).
• Ibrahim, M. A. A., Mohamed, E. A. R., Abdelrahman, A. H. M., Allemailem, K. S., Moustafa, M. F., Shawky, A. M., … Atia, M. A. M. (2021). Rutin and flavone analogs as prospective SARS-CoV-2 main protease inhibitors: In silico drug discovery study. Journal of Molecular Graphics & Modelling, 105.
• Irfan, A., Imran, M., Khalid, N., Hussain, R., Basra, M. A. R., Khaliq, T., … Assiri, M. A. (2021). Isolation of phytochemicals from Malva neglecta Wallr and their quantum chemical, molecular docking exploration as active drugs against COVID-19. Journal of Saudi Chemical Society, 25(12).
• Istifli, E. S., Netz, P. A., Tepe, A. S., Husunet, M. T., Sarikurkcu, C., & Tepe, B. (2020). In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties. Journal of Biomolecular Structure & Dynamics.
• Jain, A. S., Sushma, P., Dharmashekar, C., Beelagi, M. S., Prasad, S. K., Shivamallu, C., … Prasad, K. S. (2021). In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2. Saudi Journal of Biological Sciences, 28(1), 1040–1051. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783825/pdf/main.pdf
• Jalmakhanbetova, R. I., Suleimen, Y. M., Oyama, M., Elkaeed, E. B., Eissa, I. H., Suleimen, R. N., … Ishmuratova, M. Y. (2021). Isolation and in Silico Anti-COVID-19 Main Protease (Mpro) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana. Journal of Chemistry, 2021. https://doi.org/10.1155/2021/5547013
• Jannat, K., Paul, A. K., Bondhon, T. A., Hasan, A., Nawaz, M., Jahan, R., … Rahmatullah, M. (2021). Nanotechnology Applications of Flavonoids for Viral Diseases. Pharmaceutics, 13(11).
• Jiménez-Avalos, G., Vargas-Ruiz, A. P., Delgado-Pease, N. E., Olivos-Ramirez, G. E., Sheen, P., Fernández-Díaz, M., … Ygnacio-Aguirre, F. (2021). Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 MPRO. Scientific Reports, 11(1), 1–19. https://doi.org/10.1038/s41598-021-94951-6
• Jo, S, Kim, S., Kim, D. Y., Kim, M. S., & Shin, D. H. (2020). Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 1539–1544. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470085/pdf/IENZ_35_1801672.pdf
• Jo, Seri, Kim, S., Shin, D. H., & Kim, M. S. (2020). Inhibition of SARS-CoV 3CL protease by flavonoids. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 145–151. https://doi.org/10.1080/14756366.2019.1690480
• Johns Hopkins. (2021). Covid 19 Map Channelnewsasis. Retrieved from https://coronavirus.jhu.edu/map.html
• Johns Hopkins University. (n.d.). COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU).
• Karim, S. S. A., & Karim, Q. A. (2021). Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic. The Lancet, 398(10317), 2126–2128. https://doi.org/10.1016/s0140-6736(21)02758-6
• Khursheed, A., Jain, V., Rasool, A., Rather, M. A., Malik, N. A., & Shalla, A. H. (2021). Molecular scaffolds from mother nature as possible lead compounds in drug design and discovery against coronaviruses: A landscape analysis of published literature and molecular docking studies. Microbial Pathogenesis, 157.
• Kim, S., Thiessen, P. A., Bolton, E. E., Chen, J., Fu, G., Gindulyte, A., … Bryant, S. H. (2016). PubChem substance and compound databases. Nucleic Acids Research, 44(D1), D1202–D1213. https://doi.org/10.1093/nar/gkv951
• Kumar, B., Zaidi, S., Haque, S., Dasgupta, N., Hussain, A., Pramodh, S., … Mishra, B. N. (2021). In Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19. Current Pharmaceutical Design, 27(32), 3462–3475. Retrieved from https://www.eurekaselect.net/article/112631
• Lee, Y. G., Kang, K. W., Hong, W., Kim, Y. H., Oh, J. T., Park, D. W., … Kang, S. C. (2021). Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2. Bioorganic & Medicinal Chemistry, 45.
• Li, L. Y., Ma, L. Y., Hu, Y., Li, X. X., Yu, M., Shang, H., & Zou, Z. M. (2022). Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease. Phytochemistry, 193.
• Liao, Q., Chen, Z. Y., Tao, Y. L., Zhang, B. B., Wu, X. J., Yang, L., … Wang, Z. T. (2021). An integrated method for optimized identification of effective natural inhibitors against SARS-CoV-2 3CLpro. Scientific Reports, 11(1).
• Lin, Y., Shi, R., Wang, X., & Shen, H.-M. (2008). Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy. Current Cancer Drug Targets, 8(7), 634–646. https://doi.org/10.2174/156800908786241050
• Liskova, A., Samec, M., Koklesova, L., Samuel, S. M., Zhai, K. V, Al-Ishaq, R. K., … Kubatka, P. (2021). Flavonoids against the SARS-CoV-2 induced inflammatory storm. Biomedicine & Pharmacotherapy, 138.
• Ma, L. L., Liu, H. M., Liu, X. M., Yuan, X. Y., Xu, C., Wang, F., … Zhang, D. K. (2021). Screening S protein-ACE2 blockers from natural products: Strategies and advances in the discovery of potential inhibitors of COVID-19. European Journal of Medicinal Chemistry, 226.
• Maddah, M., Bahramsoltani, R., Yekta, N. H., Rahimi, R., Aliabadi, R., & Pourfath, M. (2021). Proposing high-affinity inhibitors from Glycyrrhiza glabra L. against SARS-CoV-2 infection: virtual screening and computational analysis. New Journal of Chemistry, 45(35), 15977–15995.
• Maiti, S., & Banerjee, A. (2021). Epigallocatechin gallate and theaflavin gallate interaction inSARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study. Drug Development Research, 82(1), 86–96. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436314/pdf/DDR-9999-na.pdf
• Majumder, R., & Mandal, M. (2020). Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: anin silicodocking and molecular dynamics simulation approach. Journal of Biomolecular Structure & Dynamics.
• Mandour, Y. M., Zlotos, D. P., & Salem, M. A. (2020). A multi-stage virtual screening of FDA-approved drugs reveals potential inhibitors of SARS-CoV-2 main protease. Journal of Biomolecular Structure & Dynamics.
• Mangiavacchi, F., Botwina, P., Menichetti, E., Bagnoli, L., Rosati, O., Marini, F., … Santi, C. (2021). Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M-pro and Its Antiviral Activity in Cells against SARS-CoV-2. International Journal of Molecular Sciences, 22(13).
• Maroli, N., Bhasuran, B., Natarajan, J., & Kolandaivel, P. (2020). The potential role of procyanidin as a therapeutic agent against SARS-CoV-2: a text mining, molecular docking and molecular dynamics simulation approach. Journal of Biomolecular Structure & Dynamics.
• Mathpal, S., Sharma, P., Joshi, T., Joshi, T., Pande, V., & Chandra, S. (2021). Screening of potential bio-molecules from Moringa olifera against SARS-CoV-2 main protease using computational approaches. Journal of Biomolecular Structure & Dynamics.
• Mohapatra, P. K., Chopdar, K. S., Dash, G. C., Mohanty, A. K., & Raval, M. K. (2021). In silico screening and covalent binding of phytochemicals of Ocimum sanctum against SARS-CoV-2 (COVID 19) main protease. Journal of Biomolecular Structure & Dynamics.
• Moradkhani, S., Farmani, A., Saidijam, M., & Taherkhani, A. (2021). COVID-19: docking-based virtual screening and molecular dynamics study to identify potential SARS-CoV-2 spike protein inhibitors from plant-based phenolic compounds. Acta Virologica, 65(3), 288–302.
• Mosquera-Yuqui, F., Lopez-Guerra, N., & Moncayo-Palacio, E. A. (2020). Targeting the 3CLpro and RdRp of SARS-CoV-2 with phytochemicals from medicinal plants of the Andean Region: molecular docking and molecular dynamics simulations. Journal of Biomolecular Structure & Dynamics.
• Neves, K. O. G., Ramos, A. S., Bruginski, E. R. D., Souza, A. D. L., Nunomura, R. D. S., Campos, F. R., … Machado, M. B. (2021). Lisboaeflavanonol A: A new flavonoid glycoside obtained from Amazonian Eugenia lisboae. Phytochemistry Letters, 43, 65–69.
• Ngwa, W., Kumar, R., Thompson, D., Lyerly, W., Moore, R., Reid, T., … Toyang, N. (2020). against COVID-19. 1–10.
• O’Boyle, N. M., Banck, M., James, C. A., Morley, C., Vandermeersch, T., & Hutchison, G. R. (2011). Open Babel. Journal of Cheminformatics, 3(33), 1–14.
• Owis, A. I., El-Hawary, M. S., El Amir, D., Aly, O., Abdelmohsen, U. R., & Kamel, M. S. (2020). Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease. Rsc Advances, 10(33), 19570–19575.
• Owis, A. I., El-Hawary, M. S., El Amir, D., Refaat, H., Alaaeldin, E., Aly, O. M., … Kamel, M. S. (2021). Flavonoids of Salvadora persica L. (meswak) and its liposomal formulation as a potential inhibitor of SARS-CoV-2. Rsc Advances, 11(22), 13537–13544.
• Potshangbam, A. M., Nongdam, P., Kumar, A. K., & Rathore, R. S. (2021). Phenylbenzopyrone of Flavonoids as a Potential Scaffold to Prevent SARS-CoV-2 Replication by Inhibiting its M-PRO Main Protease. Current Pharmaceutical Biotechnology, 22(15), 2054–2070. Retrieved from https://www.eurekaselect.net/article/113711
• Prasansuklab, A., Theerasri, A., Rangsinth, P., Sillapachaiyaporn, C., Chuchawankul, S., & Tencomnao, T. (2021). Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection. Journal of Traditional and Complementary Medicine, 11(2), 144–157.
• Puttaswamy, H., Gowtham, H. G., Ojha, M. D., Yadav, A., Choudhir, G., Raguraman, V., … Chauhan, L. (2020). In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesis. Scientific Reports, 10(1).
• Rahman, F., Tabrez, S., Ali, R., Alqahtani, A. S., Ahmed, M. Z., & Rub, A. (2021). Molecular docking analysis of rutin reveals possible inhibition of SARS-CoV-2 vital proteins. Journal of Traditional and Complementary Medicine, 11(2), 173–179.
• Rakshit, M., Muduli, S., Srivastav, P. P., & Mishra, S. (2021). Pomegranate peel polyphenols prophylaxis against SARS-CoV-2 main protease by in-silico docking and molecular dynamics study. Journal of Biomolecular Structure & Dynamics.
• Rameshkumar, M. R., Indu, P., Arunagirinathan, N., Venkatadri, B., El-Serehy, H. A., & Ahmad, A. (2021). Computational selection of flavonoid compounds as inhibitors against SARS-CoV-2 main protease, RNA-dependent RNA polymerase and spike proteins: A molecular docking study. Saudi Journal of Biological Sciences, 28(1), 448–458. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581406/pdf/main.pdf
• Rehman, M. T., AlAjmi, M. F., & Hussain, A. (2021). Natural Compounds as Inhibitors of SARS-CoV-2 Main Protease (3CLpro): A Mo-lecular Docking and Simulation Approach to Combat COVID-19. Current Pharmaceutical Design, 27(33), 3577–3589. Retrieved from https://www.eurekaselect.net/article/111556
• Rizzuti, B., Grande, F., Conforti, F., Jimenez-Alesanco, A., Ceballos-Laita, L., Ortega-Alarcon, D., … Velazquez-Campoy, A. (2021). Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs. Biomedicines, 9(4).
• Rottier, P. J. M. (1995). The Coronavirus Membrane Glycoprotein. The Coronaviridae, 115–139. https://doi.org/10.1007/978-1-4899-1531-3_6
• Rudrapal, M., Issahaku, A. R., Agoni, C., Bendale, A. R., Nagar, A., Soliman, M. E. S., & Lokwani, D. (2021). In silico screening of phytopolyphenolics for the identification of bioactive compounds as novel protease inhibitors effective against SARS-CoV-2. Journal of Biomolecular Structure & Dynamics.
• Samy, M. N., Attia, E. Z., Shoman, M. E., Khalil, H. E., Sugimoto, S., Matsunami, K., & Fahim, J. R. (2021). Phytochemical investigation of Amphilophium paniculatum; an underexploredBignoniaceae species as a source of SARS-CoV-2 M-pro inhibitory metabolites: Isolation, identification, and molecular docking study. South African Journal of Botany, 141, 421–430.
• Sen, D., Bhaumik, S., Debnath, P., & Debnath, S. (2021). Potentiality of Moringa oleifera against SARS-CoV-2: identified by a rational computer aided drug design method. Journal of Biomolecular Structure & Dynamics.
• Shaldam, M. A., Yahya, G., Mohamed, N. H., Abdel-Daim, M. M., & Al Naggar, Y. (2021). In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes. Environmental Science and Pollution Research, 28(30), 40507–40514. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088405/pdf/11356_2021_Article_14195.pdf
• Shu, Y., & McCauley, J. (2017). GISAID: Global initiative on sharing all influenza data – from vision to reality. Eurosurveillance, 22(13), 2–4. https://doi.org/10.2807/1560-7917.ES.2017.22.13.30494
• Singh, J., Malik, D., & Raina, A. (2020). Computational investigation for identification of potential phytochemicals and antiviral drugs as potential inhibitors for RNA-dependent RNA polymerase of COVID-19. Journal of Biomolecular Structure & Dynamics.
• Singh, A. V. (2021). Potential of amentoflavone with antiviral properties in COVID-19 treatment. Asian Biomedicine, 15(4), 153–159.
• Song, X., Tan, L., Wang, M., Ren, C., Guo, C., Yang, B., … Pei, J. (2021). Myricetin: A review of the most recent research. Biomedicine and Pharmacotherapy, 134, 111017. https://doi.org/10.1016/j.biopha.2020.111017
• Tyrrell, D. A., & Bynoe, M. L. (1966). Cultivation of viruses from a high proportion of patients with colds. https://doi.org/10.1016/s0140-6736(66)92364-6
• Vijayakumar, B. G., Ramesh, D., Joji, A., Prakasan, J. J., & Kannan, T. (2020). In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2. European Journal of Pharmacology, 886.
• Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., … Peng, Z. (2020). Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA - Journal of the American Medical Association, 323(11), 1061–1069. https://doi.org/10.1001/jama.2020.1585
• Wang, J., Ge, W., Peng, X., Yuan, L. X., He, S. B., & Fu, X. Y. (2021). Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis. Molecular Diversity.
• Xiao, T., Cui, M. Q., Zheng, C. J., Wang, M., Sun, R. H., Gao, D. D., … Zhou, H. G. (2021). Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M-pro and Ameliorates Pulmonary Inflammation. Frontiers in Pharmacology, 12.
• Xiao, T., Cui, M. Q., Zheng, C. J., Zhang, P. P., Ren, S. F., Bao, J. L., … Yang, C. (2021). Both Baicalein and Gallocatechin Gallate Effectively Inhibit SARS-CoV-2 Replication by Targeting M-pro and Sepsis in Mice. Inflammation.
• Xiong, Y., Zhu, G. H., Zhang, Y. N., Hu, Q., Wang, H. N., Yu, H. N., … Ge, G. B. (2021). Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL(pro): Inhibition potentials, covalent binding sites and inhibitory mechanisms. International Journal of Biological Macromolecules, 187, 976–987. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322037/pdf/main.pdf
• Xu, Z. R., Yang, L. X., Zhang, X. H., Zhang, Q. L., Yang, Z. B., Liu, Y. H., … Liu, W. K. (2020). Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening Strategy. Frontiers in Molecular Biosciences, 7.
• Xu, Z., Yang, L., Zhang, X., Zhang, Q., Yang, Z., Liu, Y., … Liu, W. (2020). Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening Strategy. Frontiers in Molecular Biosciences, 7(September), 1–8. https://doi.org/10.3389/fmolb.2020.556481
• Yosri, N., Abd El-Wahed, A. A., Ghonaim, R., Khattab, O. M., Sabry, A., Ibrahim, M. A. A., … El-Seedi, H. R. (2021). Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2. Foods, 10(8).
• Yu, R., Chen, L., Lan, R., Shen, R., & Li, P. (2020). Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking. International Journal of Antimicrobial Agents, 56(2).
• Zaki, A. A., Al-Karmalawy, A. A., El-Amier, Y. A., & Ashour, A. (2020). Molecular docking reveals the potential of Cleome amblyocarpa isolated compounds to inhibit COVID-19 virus main protease. New Journal of Chemistry, 44(39), 16752–16758.
• Zhang, Y., Yao, Y. F., Yang, Y. F., & Wu, H. Z. (2021). Investigation of Anti-SARS, MERS, and COVID-19 Effect of Jinhua Qinggan Granules Based on a Network Pharmacology and Molecular Docking Approach. Natural Product Communications, 16(5).
• Zhou, P., Yang, X. Lou, Wang, X. G., Hu, B., Zhang, L., Zhang, W., … Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7
• Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., … Tan, W. (2020). A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine, 382(8), 727–733. https://doi.org/10.1056/nejmoa2001017
• Zhu, Y., & Xie, D. Y. (2020). Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2. Frontiers in Plant Science, 11.