Kamal Ja’afar MUHAMMAD, Shajarahtunnur JAMIL, Norazah BASAR

Phytochemical study and biological activities of Scurrula parasitica L (Loranthaceae) leaves

Chemical constituents of Scurrula parasitica leaves from Loranthaceae family and some biological activitieshave been studied. Cold extractions were carried out using n-hexane, ethyl acetate and methanol to obtain the crudeextracts. Purification of the extracts led to the isolation of quercetin 1, quercitrin 2, kaempferol 3-O--L-rhamnoside 3,(+)-catechin 4, lupeol 5, lupeol palmitate 6, -sitosterol 7, squalene 8, octacosane 9, octadecane 10 and eicosane 11. Thein vitro antioxidant activity of the extracts and isolated compounds were evaluated. Compounds 1, 2, 3 and 4, togetherwith ethyl acetate and methanol extracts exhibited effective antioxidant activities against DPPH, ABTS and FRAPassays, while n-hexane and other compounds were inactive. The ethyl acetate extract gave the highest tyrosinase percentinhibition value of 66.02%, while quercetin gave the best result with tyrosinase percent inhibition value of 79.09%. Allextracts and isolated compounds showed weak activity on antimicrobial inhibition assay with the exception of quercetinwhich exhibited moderate activity against Pseudomonas aeruginosa with MIC and MBC value of 250 g/mL.

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