Prediction techniques and models are significant for people and organizations who wish to make prediction at the stage of investment and decision-making. For investors who want to achieve high earnings from investments, the stock market indexes are extremely important. Price movements in the stock such as political and social ones are affected by many factors. In the studies conducted on İstanbul Stock Exchange Index (BIST-100), the estimation generally of foreign exchange rates, interest rates, gold prices, GNP (Gross Nation Product), CPI (Consumer Price Index) and the relationship with macroeconomic variables such as the rate regard to traditional statistical prediction models were used. In this study, international advanced BIST100 Index of the estimation with Artificial Neural Network (ANN) method will be used as input instead of traditional macroeconomic variables (independent variables) and also stock market index data sets will be used. From January 2011 to December 2015 period, daily closing price of some international advanced stock market indices and BIST 100 Index data were used as data set. Data analysis were carried out through Multilayer Neural Network (MLNN) method, which is an ANN model widely used in MATLAB and the successful rate was %96,92