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life threatening adverse effects of bupropion intoxication (2), it must be fully defined. This case illustrates also the difference between intranasal or sublingual versus oral administration of bupropion.After oral administration bupropion undergoes extensive first-pass hepatic metabolismby a rate of 95%. When taken by intranasal or sublingual route the alteration in bupropion disposition may lead to increased plasma levels due to lack of first- pass metabolism. Psychiatrists should keep in mind recreational abuse potential of bupropion and different routes of administration especially in patients who have abuse potential