Thyroid disorders associated with Hepatitis C or interferon based therapies

Karaciğer dışı birçok hastalık kronik hepatit C virüs (HCV) enfeksiyonu (hematolojik hastalıklar, böbrek hastalığı, dermatolojik problemler) ile ilişkilendirilmiştir. HCV enfeksiyonunun klinik ya da subklinik oto-immün tiroid hastalıklarının artmış insidansıyla da ilişkili olduğu gösterilmiştir. Ayrıca, kronik HCV enfeksiyonunun interferon (IFN)-α ile tedavisi vakaların % 40’ına kadar olan kısmında subklinik veya klinik tiroidit ile ilişkilidir. İnterferon ilişkili tiroidit (İİT), otoimmün tip ve otoimmün olmayan tip olarak sınıflandırılabilir. Mevcut çalışmalar viral yük, viral genotip ve tedavi rejiminin kronik hepatit C hastalarında İİT gelişimini etkilemediğini, ayrıca İİT gelişmesinin kalıcı viral yanıt (KVY) için bir gösterge olmadığını, ancak, genetik faktörler, cinsiyet, HCV enfeksiyonu ve tiroid antikor (TAb) pozitifliğinin rol oynayabileceğini göstermektedir

Anahtar Kelimeler:

Hepatit C, interferon, tiroid hastalıkları

Thyroid disorders associated with Hepatitis C or interferon based therapies

Şener Barut, ÖZGÜR GÜNAL Several extrahepatic diseases have been associated with chronic hepatitis C virus (HCV) infection (i.e. hematologic diseases, renal disease, dermatologic conditions). It has also been shown that HCV infection is associated with increased incidence of clinical and subclinical autoimmune thyroid disorders. Moreover, interferon (IFN)-α therapy of chronic HCV infection is associated with subclinical or clinical thyroiditis in up to 40% of cases. Interferon induced thyroiditis (IIT) can be classified as autoimmune type and non-autoimmune type. Current studies indicate that viral load, viral genotype and therapeutic regimen do not influence development of IIT in chronic hepatitis C patients thus, and development of IIT is not a predictor of sustained viral response. However, evidence suggests that genetic factors, gender, HCV infection and positivity of thyroid antibodies may play role.

Keywords:

Hepatitis C, interferon, thyroid disorders,

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