Ramesh BHAT.Y, K SHRUTHİ, Ms PADMA, Sr VAMSİ, G Sherin, K ANNAMMA

Spontaneous recovery of haemophagocytic syndrome in an adolescent girl receiving anti-tuberculosis treatment

Enfeksiyon ilişkili hemofagositik sendrom (HPS) nadirdir ve potansiyel olarak ölümcül olabilir. Reaktif HPS, tüberküloz dâhil olmak üzere çeşitli enfeksiyonlarla birlikte bildirilmiştir. Tüberküloz ilişkili HPS erişkinlerde çocuklara göre daha sık görülür. Tüberküloz tedavisi ile birlikte HPS ilişkili şiddetli pansitopeni nadiren bildirilmiştir. Tedavi başarısı tedavinin erken başlamasına bağlıdır. Bu makalede anti-tüberküloz tedavisi sırasında ciddi pansitopeni gelişen 13 yaşında bir kız çocuğu sunulmaktadır. Kemik iliği aspirasyonunda trilineage dispoyez, debris fagosite etmiş histiyositler ve reaktif HPS’yi gösteren hemofagositoz vardı. Hasta destek tedavisi ile tamamen iyileşti

Anahtar Kelimeler:

Tüberküloz, pansitopeni, hemofagositoz, kendiliğinden iyileşme

Spontaneous recovery of haemophagocytic syndrome in an adolescent girl receiving anti-tuberculosis treatment

Ramesh Bhat.Y, K Shruthi, MS Padma, SR Vamsi, G Sherin, K Annamma Infection associated haemophagocytic syndrome (HPS) is rare and could be potentially fatal. Reactive HPS has been reported with various infections including tuberculosis. Tuberculosis associated HPS is more common in adults than in children. Severe pancytopenia due to HPS complicating tuberculosis and while on therapy has been rarely described. Success of therapy depends on early initiation of treatment. We describe herein a 13-years old girl who developed severe pancytopenia while on anti-tuberculous treatment. Her bone marrow aspirate showed trilineage dyspoiesis, histiocytes with phagocytosed debris and haemophagocytosis confirming a reactive haemophagocytic syndrome. She recovered completely with supportive treatment.

Keywords:

tuberculosis, pancytopenia, haemophagocytosis, spontaneous recovery,

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