Septic arthritis caused by Aspergillus fumigatus in an immunosuppressive patient: A case report and review of the literature
Septic arthritis caused by Aspergillus fumigatus in an immunosuppressive patient: A case report and review of the literature
Septic arthritis is a serious medical problem that causes rapidly chronic and irreversible joint damage when diagnosis and treatment are delayed. Although, the bacteria are the most frequent cause of septic arthritis, rarely fungi may be responsible for this disease. We presented here a case of septic arthritis caused by Aspergillus fumigatus, developed in a 65 years-old-male patient with diabetes mellitus. The patient admitted to our hospital with complaints of pain, swelling, redness in the right knee and high fever, which are not exceeding despite using vancomycin and ceftriaxone for 18 days. Imipenem was started to the patient in our hospital. At the end of 7 days because of no regression of patient\'s complaints, arthroscopic synovectomy and lavage were performed for the patient\'s right knee. Aspergillus fumigatus was isolated from the aspiration biopsy specimen that received during the surgical operation and patient was treated with voriconazole, successfully.
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- Garcia-Arias M, Balsa A, Mola EM. Septic arthritis. Best Pract Res Clin Rheumatol 2011; 25:407-21.
- Sung-Wook C, Tong-Joo L, Myung-Ku K, Moon L, Jae-Ho J. A Case of Fungal Arthritis Ca-used by Hansenula Anomala. Clin Orthop Surg 2010; 2:59-62.
- Mekan SF, Saeed O, Khan JA. Invasive aspergillosis with polyarthritis. Mycoses 2004; 47:518-20.
- Zmeili OS, Soubani AO. Pulmonary aspergillosis: a clinical up- date. QJM 2007; 100:317-34.
- Shahnazi A, Mansouri N, Malek A, Sepehri Z, Mansouri SD. Is Pulmonary Aspergillosis Common in Diabetes Mellitus Pa- tients? Tanaffos 2010; 9:69-74.
- Golmia R, Bello I, Marra A, Hamerschlak N, Osawa A, Schein- berg M. Aspergillus fumigatus joint infection: a review. Semin Arthritis Rheum 2011; 40:580-4.
- Garcia-Porrua C, Blanco FJ, Atanes A, Torres P, Galdo F. Sep- tic arthritis by Aspergillus fu-migatus: a complication of corti- costeroid infiltration. Br J Rheumatol 1997; 36:610-1.
- Denes E, Boumediene A, Durox H, et al. Voriconazole con- centrations in synovial fluid and bone tissues. J Antimicrob Chemother 2007; 59:818-9.
- Sharada DM, Arunkumar G, Vandana KE, Rao PS. Sino- orbital aspergillosis in a diabetic pa-tient. Indian Journal of Medical Microbiology 2006; 24:138-40.
- Steinfeld S, Durez P, Hauzeur JP, Motte S, Appelboom T. Ar- ticular aspergillosis: two case reports and review of the litera- ture. Br J Rheumatol 1997; 36:1331-4.
- Sohail MR, Smilack JD. Aspergillus fumigatus septic arthritis complicating intra-articular corticosteroid injection. Mayo Clin Proc 2004; 79:578-9.
- Yu OH, Keet AW, Sheppard DC, Brewer T. Articular aspergil- losis: case report and review of the literature. Int J Infect Dis ; 14:433-5. Golmia R, Bello I, Marra A, Hamerschlak N, Osawa A, Scheinberg M. Aspergillus fumigatus joint infection: a review. Semin Arthritis Rheum 2011; 40:580-4.