Middle East Respiratory Syndrome: MERS

Orta Doğu Solunum Sendromu coronovirüsü (MERS-CoV) yeni ortaya çıkan bir solunum virüsüdür. Bu virus ilk olarak 2012 yılında Suudi Arabistan’da tanımlanmıştır. Orta Doğu solunum sendromu koronavirüs enfeksiyonu akut hafif bir hastalık ile fulminan hastalık arasında değişen bir klinik spektrum ile karakterizedir. Hastaların çoğunluğunda ateş, ateş ile titreme, öksürük, nefes darlığı ve kuru öksürük bildirilmiştir. İnsandan insana bulaşan vakalar belgelenmiştir. MERSCoV enfeksiyonu için günümüzde özel bir tedavi ve aşılama yoktur. Sürveyans ve infeksiyon kontrol önlemleri halk sağlığı için hayati öneme sahiptir

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging respiratory virus. It was first identified in Saudi Arabia in 2012. MERS-CoV infection is characterized by a spectrum of illness ranging from mild to acute and fulminant disease. The majority of patients present with fever, fever with chills/rigors, cough, shortness of breath, and dry cough. Cases of human-to-human transmission have been documented. There is currently no specific treatment and vaccination for MERS-CoV infection. Surveillance and infection-control measures are of vital importance to an ef­ficient public health response. J Microbiol Infect Dis 2015;5(2): 93-98Key words: Coronavirus, Middle East Respiratory Syndrome, MERS-CoV polymerase-chain-reaction, respiratory symptoms

___

De Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the coronavirus

study group. J Virol 2013;87:7790-7792.

MacIntyre CR. The discrepant epidemiology of Middle East respiratory

syndrome coronavirus (MERS-CoV). Environ Syst Decis 2014;34:383-390.

Bermingham A, Chand MA, Brown CS, et al. Severe respiratory illness

caused by a novel coronavirus, in a patient transferred to the United

Kingdom from the Middle East, September 2012. Euro Surveill.

;17:20290.

Announcement of the Coronavirus Study Group. Middle East Respiratory Syn 1 drome Coronavirus (MERS-CoV). J. Virol 2013;87:7790-7792.

Raj VS, Osterhaus AD, Fouchier RM, et al. MERS: emergence of a

novel human coronavirus. Curr Opin Virol 2014;5:58-62.

Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel

coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012;367:1814-1820.

Al-Tawfiq JA, Assiri A, Memish ZA. Middle East respiratory syndrome

novel corona (MERS-CoV) infection Epidemiology and outcome update.

Saudi Med J 2013;34:991-994.

World Health Organization. Global alert and response (GAR): andemic

and epidemic diseases (http://www.who.int/csr/disease/en/)

Guery B, Poissy J, el Mansouf L, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory syndrome coronavirus: A report of nosocomial transmission. Lancet

;381:2265-2272.

Breban R, Riou J, Fontanet A. Interhuman transmissibility of Middle

East respiratory syndrome coronavirus: estimation of pandemic risk.

Lancet 2013;382:694-699.

Memish ZA, Zumla AI, Al-Hakeem RF, et al. Family cluster of Middle

East respiratory syndrome coronavirus infections. N Engl J Med

;368:2487-2494.

Health Protection Agency (HPA) UK Novel Coronavirus Investigation

Team. Evidence of person-to-person transmission within a family

cluster of novel coronavirus infections, United Kingdom, February

Euro Surveill 2013;18:20427.

Puzelli S, Azzi A, Santini MG, et al. Investigation of an imported case of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection

in Florence, Italy, May to June 2013. Euro Surveill 2013;18:20564.

Abroug F, Slim A, Ouanes-Besbes L. Family cluster of Middle East

respiratory syndrome coronavirus infections, Tunisia, 2013 Emerg

Infect Dis 2014;20:1527-1530.

Assiri A, McGeer A, Perl TM, et al. Hospital outbreak of Middle East

respiratory syndrome coronavirus. N Engl J Med 2013;369:407-416.

Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of

the Middle East respiratory syndrome coronavirus in Saudi Arabia: a

descriptive genomic study. Lancet 2013;382:1993-2002.

Omrani AS, Matin MA, Haddad Q, et al. A family cluster of Middle East

respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case. Int J Infect Dis 2013;17:e668-

e672.

De Sousa R, Reusken C, Koopmans M. MERS coronavirus: Data

gaps for laboratory preparedness. J Clin Virol 2014;59:4-11.

Bauch CT, Oraby T. Assessing the pandemic potential of MERS-CoV.

Lancet 2013;382:662-664.

Drosten C, Seilmaier M, Corman VM, et al. Transmission of MERSCoronavirus in household contacts. N Engl J Med 2014;371:828-835.

Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 2013;13:752-761.

Memish ZA, Almasri M, Turkestani A, et al. Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program. Int J Infec Dis 2014;25:186-190.

Eckerle I, Müller MA, Kallies S, et al. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J 2013;10:359.

Memish ZA, Al-Tawfig JA, Makhdoom HQ, et al. Screening for Middle

East respiratory syndrome coronavirus infection in hospital patients

and their healthcare worker and family contacts: a prospective descriptive study. Clin Microbiol Infect 2014;20(5):469-474.

http://who.int/csr/disease/coronavirus_infections/MERS_home

Memish MA, Cotton M, Meyer B, et al. Human Infection with MERS

Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013.

Emerg Infect Dis 2014;20:1012-1015.

Reusken CB, Lina PH, Pielaat A, et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis 2013;13:859-

-

Azhar EI, El-Kafrawy S A, Farraj S A, et al. Evidence for Camelto-Human Transmission of MERS Coronavirus. N Engl J Med 2014;370:2499-2505.

Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of

the Middle East respiratory syndrome coronavirus in Saudi Arabia: a

descriptive genomic study. Lancet 2013;382:1993-2002.

Corman V, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction.Euro Surveill 2012;17:20285.

Hijawi B, Abdallat M, Sayaydeh A, et al. Novel coronavirus infections

in Jordan, April 2012: epidemiological findings from a retrospective

investigation. East Mediterr Health J. 2013;19:S12-18.

Momattin H, Mohammed K, Zumla A, et al. Therapeutic Options for

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) - possible

lessons from a systematic review of SARS-CoV therapy. Int J Infect Dis 2013;17:e792-e798.

Balkhair A, Al Maamari K, Alawi FB. The struggle against MERS-CoV

(The Novel Coronavirus). Oman Med J 2013;28:226-227.

Wilde AH, Raj S, Oudshoorn D, et al. MERS-coronavirus replication

induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment. J Gen Virol 2013;94:1749-1760.

Omrani AS, Saad MM, Baig K, et al. Ribavirin and interferon alfa-2a

for severe Middle East respiratory syndrome coronavirus infection:

a retrospective cohort study. Lancet Infect Dis 2014;14:1090-1095.

Pavli A, Tsiodras S, Maltezou HC. Middle East respiratory syndrome

coronavirus (MERS-CoV): Prevention in travelers. Travel Med and

Infect Dis 2014;12:602-608.

Journal of Microbiology and Infectious Diseases-Cover
  • ISSN: 2146-3158
  • Başlangıç: 2011
  • Yayıncı: Sağlık Araştırmaları Derneği
Sayıdaki Diğer Makaleler

Isolated testicular tuberculosis masquerading as a testicular tumor

Chakrabarti INDRANİL, Das VASWATİ, Ghosh NİLANJANA

An unusual cause of orchiectomy: Brucella epididymo-orchitis that does not respond to the treatment

M. Fatih Erkoç, Sevil Alkan

Staphylococcus lugdunensis bacteraemia secondary to an infected intracardiac fragment of a vascular access device

Lisa GRİMAUD, Josephine BİGENİ, Matthew BALBİ, Nina NESTOROVA, Walter BUSUTTİL, Tonio PİSCOPO

Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever

Ayşe ERTÜRK, Erkan CÜRE, Emine PARLAK, Medine CÜRE, Süleyman YÜCE, Zulal ÖZKURT

Prevalence of Extended Spectrum Beta-Lactamases among Escherichia coli and Klebsiella spp isolates in Manipal Teaching Hospital, Pokhara, Nepal

Shristi RAUT, Shishir GOKHALE, Bipin ADHİKARİ

Evaluation of Anti-Nuclear antibody test results in clinical practice

Nevreste ÇELİKBİLEK, Birsen ÖZDEM, Ziya AÇIKGÖZ

Middle East Respiratory Syndrome: MERS

Emine Parlak

Epidemiology of carbapenemase producing Enterobacteriaceae in a general hospital

Amina KANDEEL

Correlates of adherence and utilization of Isoniazid preventive therapy in HIV patients

Yitagesu GETACHEW, Wubegzier MEKONNEN

Primary hepatic actinomycosis mimicking a tumor (inflammatory pseudotumor): Case report and literature review

Ayşe BATİREL, Ferhat ARSLAN, Sevinç KESER, Hasan KÜCÜK, Dilek YAVUZER, Oğuz KARABAY, Serdar ÖZER