Öz
Pseudallescheria boydii, a rare cause of infection in humans, are saprofitic microorganisms which are found in soil. In this report, we describe a renal transplant patient who had a skin-soft tissue infection at the anterior side of her left tibia due to P. boydii. Tissue biopsy was taken from her tibial lesion. Pathologic examination revealed hyphae plus fungal spores and mycological cultures were positive for P. boydii. The fungus was also identified by molecular methods. Fluconazole and topical isoconazole nitrate were given to the patient until the antifungal susceptibility results were seen. Fluconazole was changed to itraconazole via susceptibility results. Clinical response was seen at the 1 month control. Because of limited data regarding the optimal antifungal drug choice and duration of treatment for P. boydii infections, the proper identification of pathogen and antifungal susceptibility tests have vital importance. J Microbiol Infect Dis 2015;5(4): 176-179Key words: Pseudallescheria boydii, renal transplant, soft tissue infection
___
Jayamohan Y, Ribes JA. Pseudallescheriasis: a summary of
patients from 1980-2003 in a tertiary care center. Arch Pathol Lab Med. 2006;130:1843-1846.
Troke P, Aguirrebengoa K, Arteaga C, et al. Treatment of scedosporiosis with voriconazole: clinical experience with 107
patients. Antimicrob Agents Chemother 2008;52:1743.
Turin L, Riva F, Galbiati G, Cainelli T. Fast, simple and highly
sensitive double-rounded polymerase chain reaction assay to detect medically relevant fungi in dermatological specimens.Eur J Clin Invest. 2000;30:511-518.
Hall TA. BioEdit: a user-friendly biological sequence alignment
editor and analysis program for Windows 95/98 NT. Nucl Acids
Symp Ser. 1999;41:95-98.
Cardoso JC, Serra D, Cardoso R, et al. Cutaneous Pseudallescheria
boydii infection in a renal transplant patient: A case report. Dermatol Online J 2009;15:8.
Gottesman-Yekutieli T, Shwartz O, Edelman A, et al. Pseudallescheria boydii infection of a prosthetic hip joint-an uncommon infection in a rare location. Am J Med Sci 2011;342:250-
-
Chaveiro MA, Vieira R, Cardoso J, Afonso A. Cutaneous infection due to Scedosporium apiospermium in an immunosuppressed
patient. J Euro Acad Dermatol Venereol 2003;17:47-49.
Zeng J, Kamei K, Zheng Y, Nishimura K. Susceptibility of P.
boydii and Scedosporium apiospermum to new antifungal agents. Jpn J Med Mycol 2004;45:101-104.
Campagnaro EL, Woodside KJ, Early MG, et al. Disseminated
Pseudallescheria boydii (Scedosporium apiospermum)infection in a renal transplant patient. Transpl Infect Dis 2002;4:207-211.