Steven TOFFEL, Lymaries VELEZ, Elizabeth TREMBLAY, Kairav SHAH, Kenneth RAND, Jena AUERBACH, Kathryn Anne POTTER, Stacy G. BEA
Exploring the Less Common Pathogens of Infectious Diarrhea
ABSTRACT
Objective: Gastrointestinal (GI) panels have allowed for faster
and accurate detection, treatment, and control of pathogens. Because of the
large number of potential pathogens included in the panel the clinical
significance and manifestations of some organisms, such as Enteroaggregative Escherichia coli (EAEC) and
Enteropathogenic E. coli (EPEC),
remains undetermined.
Methodology: We performed a single-institution retrospective chart
review for 222 patients with a stool sample tested on BioFire FilmArray
Gastrointestinal Panel (GI Panel) between June 1, 2016 and March 9, 2017.
Results:
Of
the 222 patients, four had EAEC and 17 and EPEC. Patients who tested positive
for EAEC and EPEC were younger (26.3 years and 33.9 years, respectively) than
patients that did not test positive for a GI pathogen (47.7 years). In cases
where multiple organisms were detected, EPEC was present 56.3% of the time.
Analysis of symptoms showed that EPEC patients had a high prevalence of
abdominal pain (p=0.0425) and vomiting (p=0.0045), but not diarrhea, when
compared to the presence of these symptoms in patients with no targets
detected. With only four patients positive for EAEC in this study, the results
of symptoms in EAEC patients were inconclusive. Cases involving EPEC and EAEC
were treated similarly to other cases of diarrhea with no significant
difference in the number of imaging studies and medication changes.
Conclusions: While further studies
are required to determine the specific clinical significance of EAEC or EPEC,
it is evident that patients positive for EPEC often experience abdominal pain
and diarrhea, suggesting EPEC may be more pathogenic than previously thought. J
Microbiol Infect Dis 2019; 9(1):1-9.
Keywords:
Diarrhea, Gastrointestinal Panel, Escherichia coli,
___
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- ISSN: 2146-3158
- Başlangıç: 2011
- Yayıncı: Sağlık Araştırmaları Derneği
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