Graves hastalığının nadir bir prezentasyonu: bilateral gode bırakan bacak ödemi
Graves hastalığının birçok ekstratiroidal manifestasyonu bulunmaktadır. Literatürde hipertiroidizm vakalarında bilateral gode bırakan pretibial ödem az sayıdaki olgu sunumlarında bildirilmiştir. Bu sunumda, henüz iki haftadır el ve bacak şişlikleri olan ve tedavi ile hızla bulguları gerileyen bir Graves olgusunu sunduk. Birçok etyolojiye bağlı olarak ortaya çıkabilen diffüz, gode bırakan pretibial ödem hipertiroidizm ayırıcı tanısında da göz önünde bulundurmalıdır.
Anahtar Kelimeler:
Graves hastalığı, hipertiroidizm, ödem
A rare presentation of Graves’ disease: bilateral pitting edema of the legs
Graves’ disease has many extrathyroidal manifestations. In the literature, bilateral pretibial pitting edema in hyperthyroidism cases has been reported in a few case reports. In the current presentation, we report a case of Graves who had leg and hand swelling for two weeks and whose findings regressed rapidly with treatment. Diffuse, bilateral pitting pretibial edema, which may occur due to many etiologies, should also be considered in the differential diagnosis of hyperthyroidism.
Keywords:
Graves’ disease, hyperthyroidism, edema,
___
- Ai J, Leonhardt JM, Heymann WR. Autoimmune thyroid diseases: etiology, pathogenesis, and dermatologic manifestations. J Am Acad Dermatol 2003; 48: 641-59.
- Schwartz KM, Fatourechi V, Ahmed DD, Pond GR. Dermopathy of Graves’ disease (pretibial myxedema): long-term outcome. J Clin Endocrinol Metab 2002; 87: 438-46.
- Chajek T, Romanoff H. Cushing syndrome with cyclical edema and periodic secretion of corticosteroids. Arch Intern Med 1976; 136: 441-3.
- Mahajan SK, Machhan PC, Sood, BR, et al. Pitting edema in hypothyroidism. J Assoc Physicians India 2003; 51: 885.
- Hataya Y, Akamizu T, Kanamoto N, Moriyama K, Shimatsu A, Nakao K. A case of subclinical hypothyroidism developing marked pleural effusions and peripheral edema with elevated vascular endothelial growth factor. Endocr J 2007; 54: 577-84.
- Osuna PM, Udovcic M, Sharma MD. Hyperthyroidism and the Heart. Methodist Debakey c-Cardiovasc J 2017; 13: 60-3.
- Chapman EM, Maloof F. Bizarre clinical manifestations of hyperthyroidism. N Engl J Med 1956; 254: 1–5.
- Toft JC, Larsen S. Tendency to edema as the initial symptom of hyperthyroidism. Ugeskr Laeger 1992; 154: 90-1.
- Kazama I, Mori Y, Baba A, Nakajima T. Pitting type of pretibial edema in a patient with silent thyroiditis successfully treated by angiotensin ii receptor blockade. Am J Case Rep 2014; 15: 111-4.
- Volke V, Matjus S. Unilateral pitting edema of the leg as a manifestation of Graves’ disease: a case report. J Med Case Rep 2012; 6: 258.
- Novella BA, Blanco FQ, Suarez CF, Garcia IP, Molden-Hauer FD. Edema as clinical manifestation of hyperthyroidism. Report of 2 cases. An Med Interna 1996; 13: 81-3.
- Kukol’nikova EL, Lapina NV. Etiology and pathogenesis of secondary edema of the lower extremities in patients with limited pretibialnoy myxedema on the background of hyperthyroidism. Khirurgiia (Mosk) 2011; 9: 67-70.
- Başlangıç: 2020
- Yayıncı: MediHealth Academy Yayıncılık