Eman Hussein ABED, Nadia İmad AL AMEEN, Liqaa Ali JAZAA

Extraction of Chitosan from Kentish Snail Exoskeleton Shellʼs, Monacha cantiana (Montagu, 1803) for the Pharmaceutical Application

Chitin and chitosan are a natural polysaccharide prepared by processing Kentish snail exoskeletonʼs (species Monacha cantiana) which involves by partial deacetylation of chitin. Chitosan considered the second most abundant natural polymer. Many researchers have found that chitosan very important bioactive polymer as biodegradable and nontoxic material which made wide applicability in conventional pharmaceutics as a potential formulation excipient. This study is interested in the extraction of chitosan, with low molecular weight and suitable, for pharmaceutical industry. The crude chitin was collected from exoskeleton of Monacha cantiana specimens to obtain chitosan. The current study was synthesized from chitosan usage for the pharmaceutical industry.

Keywords:

Chitin, extraction chitosan, pharmaceutical industry, biodegradabl,

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ASTM American Standard Test Method, (2003) Method for determining degree of deacetylation in chitosan salts by proton nuclear magnetic resonance (1H NMR) spectroscopy,13, F2260-2265.
Dutta PK, Ravikumar MnV, Dutta J, (2002) Chitin and chitosan for versatile applications. JMS polym Rev, 42, 307.
Guibal E, (2004) Interactions of metal ions with chitosan-based sorbents: A review Separation and Purification Technology, 38, 43-74.
Huang M, (2004) Uptake and cytotoxicity of chitosan molecules and nanoparticles: Effects of molecular weight and degree of deacetylation. Pharmaceutical Research, 21, 344-353.
Kathuria N, Tripathi A, Kar KK, Kumar A, (2009) Synthesis and characterization of elastic and macroporous chitosan–gelatin cryogels for tissue engineering. Actabiomaterialia, 5, 406-418.
Klug M, Sanches MNM, Laranjeira MCM, Favere VT, Rodrigues CA, (1998) Anlise das isotermas de adsorço de Cu(II), Cd(II), Ni(II) e Zn(II) pela N-(3, 4- dihidroxibenzil) quitosanaempregando o método da regresso no linear. Quimica Nova, 21, 410-413.
Kumar MNVR, (2000) A review of chitin and chitosan applications. Reactive and Functional Polymers, 46, 1-27.
Kurita K, (2006) Chitin and chitosan functional biopolymers from marine crustaceans. Marine Biotechnology, 8, 203-226.
Lamarque G, (2005) Physicochemical behavior of homogeneous series of acetylated chitosans in aqueous solution: role o f various structural parameters. Biomacro-molecules, 6, 131-142.
Le Y, Anand SC, Horrocks AR, (1997) Recent developments in fiber and materials for wound management. Indian Journal Fiber Text Res, 22, 337.
Lertsutthiwong P, How NC, Chandrkrachan S, Stevens WF, (2002) Effect of chemical treatment on the characteristics of shrimp chitosan. Journal of metals, materials and minerals, 12, 11-18.
Lim S, Hudson SM, (2003) Review of chitosan and its derivatives as antimicrobial agents and their uses as textile chemicals. JMS Polym Rev, 43, 223.
Muzzarelli RAA, (1997) Some Modified Chitosan and their Niche applications, Chitin. Hanbook, edited by RAA Muzzarelli and M G peter (European Chitin Society, Italy),pp. 47-53.
Muzzarelli RAA, Rochetti R, (1985) Determination of the degree of acetelation of chitosans by first derivative ultraviolet spectrophotometry. carbohydrpolym, 5, 461-472.
Tan H, Chu CR, Payne KA, Marra KG, (2009) Injectable in situ forming biodegradable chitosan–hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials,30, pp.2499-2506.
Toan NV, (2009) Production of Chitin and Chitosan from Partially Autolyzed Shrimp Shell Materials. The Open Biomaterials Journal, 1, 21-24.
Trung TS, Thein-Han WW, Qui NT Ng CH, Stevens WF, (2006) Functional characteristics of shrimp chitosan and its membranes as affected by the degree of deacetylation. Bioresource Technology, 97, 659-663.