Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü

Büyüme ve gelişme ile yara iyileşmesi gibi fi zyolojik süreçlerde doku beslenme mekanizmasının doğru çalışması organ gelişimi ve fonksiyonu için önemlidir. Kanser gibi kontrolsüz ve disfonksiyonel büyüme ile devam eden patolojik süreçlerde ise damar oluşumunun önlenmesi tedavi açısından önem taşır. Damarlanmanın oluşmasında temel molekül olan; VEGF mitogenez, anjiyogenez ve endotelyal fonksiyonların düzenlenmesi dahil birçok önemli görev yapar. Bu makale ile; damar oluşum mekanizmaları, görevli büyüme faktörleri, bu faktörlerin etkileştiği reseptör yapıları ve bu etkileşime neden olan koşulların belirtilmesi amaçlanmıştır

Anahtar Kelimeler:

Angiogenesis, VEGF, VEGFR

Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü

Tıp Fakültesi Dekanlığı, Korucuk Mahallesi, Konuralp Bulvarı,No:81/1 Korucuk Kampüsü, Adapazarı/SakaryaTel: 0 (264) 295 66 30 Fax: 0 (264) 295 66 29 ankara.medicine@gmail.com

Keywords:

Angiogenesis, VEGF, VEGFR,

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