Hüseyin ESMER, Salih CESUR, Çiğdem ATAMAN HATİPOĞLU, Esra KAYA KILIÇ, Sami KINIKLI, Güler VAHABOĞLU

Vankomisin tedavisine bağlı olarak red neck sendromu gelişen penisiline dirençli pnömokok menenjiti olgusu

Vankomisine bağlı olarak gelişen yan etkilerden red neck (kırmızı boyun) sendromu histamin aşırı salınımına bağlı bazen hayatı tehdit edebilen bir komplikasyondur. Red neck sendromu gelişen hastalarda zorunlu hallerde kortikosterod ve antihistaminiklerle birlikte vankomisin tedavisine devam edilebilir veya alternatif bir antibiyotik tedavisine geçilebilir. Bu yazıda, penisiline dirençli pnömokok menenjiti tanısıyla vankomisin tedavisi başlanan ve tedavinin 8. gününde red neck sendromu gelişen 54 yaşında bir kadın hasta sunuldu. Hastanın o sabah verilen vankomisin infüzyonunun bir saatten kısa sürdüğü öğrenildi. Hastanın vankomisin tedavisi kesilerek intravenöz linezolid tedavisine geçildi. Sonuç olarak, vankomisinin hızlı infüzyonuna bağlı olarak red neck sendromu gelişebilir ve bu olgularda tedavi yönetiminde alternatif ilaç olarak linezolid kullanılabilir.

Anahtar Kelimeler:

Penisiline dirençli pnömokok, menenjit, vankomisin, yan etki, red neck sendromu, , tedavi yönetimi

A case of penicillin resistant pneumococcal meningitis who developed red neck syndrom due to vancomycin therapy

Red neck syndrome which is a side effect of vancomycin, is associated with excessive release of histamine and is sometimes a life threatening complication. In patients who develop red neck syndrome, if necessary, vancomycin therapy may be continued with corticosteroids and antihistamines or an alternative antibiotic may be started. In this report, a 54 year-old female patient who was started vancomycin therapy because of penicillin resistant pneumococcal meningitis and developed red neck syndrome on 8th day of the therapy was presented. It was learned that the patient's vancomycin infusion that morning was shorter than one hour. Vancomycin therapy was stopped and intravenous linezolide was started. In conclusion, red neck syndrome may develop due to rapid infusion of vancomycin. In this patients linezolide may be used as alternative therapy.

Keywords:

Penicillin resistant pneumococcus, meningitis, vancomycin, side effect, red neck syndrome, , management,

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