Streptococcus agalactiae suşlarının antimikrobiyal direnç paterni: beş yıllık tek merkez değerlendirmesi
Amaç: Streptococcus agalactiae’nın ciddi neanatal ve postpartum enfeksiyonlara neden olduğu bilinmektedir. Ayrıca immünsupresif hastaları da etkilemektedir. Bu hastalıkların tedavisinde penisilin ilk tercih edilen antimikrobiyal ajandır. Ancak penisilin alerjisi olan hastalar, son zamanlarda bildirilen penisilin toleransı ve diğer alternatif antimikrobiyal ajanlara karşı artan direnç oranları tedaviyi zorlaştırmaktadır. Bu çalışmada çeşitli klinik örneklerden izole edilen GBS suşlarında antibiyotik direnç profillerini belirleyerek daha etkili tedaviye katkıda bulunmayı amaçladık.Gereç ve Yöntem: 2012 - 2016 yılları arasında klinik mikrobiyoloji laboratuvarında çeşitli klinik örneklerden izole edilen toplam 80 GBS suşu retrospektif olarak değerlendirilmiştir. Bakteri identifikasyonu ve antibiyotik duyarlılık testleri konvansiyonel metodlar ve VITEK®-2 (BioMérieux, Fransa) otomatize identifkasyon cihazı kullanılarak yapılmıştır.Bulgular: Tüm GBS izolatları penisilin, imipenem, meropenem, linezolid, trimetoprim sulfametoksazol, tigesiklin, teikoplanin ve vankomisine duyarlı bulunmuştur. İzolatların tetraksiklin, eritromisin, siprofloksasin, klindamisin, moksifloksasin ve ampisilin direnç oranları ise sırasıyla %91,5, %50,0, %31,0, %23,7, %23,3 ve %2,9’dur. Sonuç: Çalışmamızda bölgemizde GBS izolatlarında penisiline direnç görülmemiştir. Penisilin, bu enfeksiyonların tedavisinde ilk tercih edilen ajan olarak kullanılmaktadır. Ancak alternatif ilaçlarda artan direnç oranları göz önüne alındığında GBS enfeksiyonlarının etkin tedavi ve profilaksisi için antimikrobiyal duyarlılık testlerinin yapılması önerilir.
Anahtar Kelimeler:
Grup B streptokok, penisilin, antimikrobiyal duyarlılık
Antimicrobial resistance pattern of Streptococcus agalactiae strains: five years evaluation of single center’
Aim: Streptococcus agalactiae is known to cause severe neonatal and postpartum infections. It also affects immunosuppressive patients. Penicillin is the first preferred antimicrobial agent in the treatment of these diseases. However, recent reports of penicillin tolerance and increased resistance to alternative antimicrobial agents in patients with penicillin allergies make treatment more difficult. In this study, we aimed to contribute to more effective treatment by determining antibiotic resistance profiles in GBS strains isolated from various clinical specimens. Material and Method: A total of 80 GBS strains isolated from various clinical specimens in clinical microbiology laboratory between 2012 and 2016 were evaluated retrospectively. Bacterial identification and antibiotic susceptibility tests were performed using conventional methods and an automated identification analyzer VITEK®-2 (BioMérieux, France).Results: All GBS isolates were found as susceptible to penicillin, imipenem, meropenem, linezolid, trimethoprim sulfamethoxazole, tigecycline, teicoplanin and vancomycin. The resistance rates of tetracycline, erythromycin, ciprofloxacin, clindamycin, moxifloxacin and ampicillin in isolates were 91.5%, 50.0%, 31.0%, 23.7%, 23.3% and 2.9% respectively. Conclusion: In our study, penicillin resistance was not observed in GBS isolates. Penicillin has been using as the first preferred agent in the treatment of these infections. However, considering the increasing resistance rates in alternative drugs, antimicrobial susceptibility testing for the effective treatment and prophylaxis of GBS infections is suggested.
Keywords:
Group B streptococcus, penicillin, antimicrobial susceptibility,
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- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 2018
- Yayıncı: MediHealth Academy Yayıncılık