Polikistik over sendromunda inflamatuvar belirteçlerin serum seviyeleri ve monosit/yüksek yoğunluklu lipoprotein oranı

Amaç: Bu çalışma polikistik over sendromu hastalarında ve sağlıklı kadınlarda TNFα, hsCRP ve monosit/yüksek yoğunluklu lipoprotein (M/HDL) seviyeleri arasındaki farkı değerlendirmeyi amaçlamaktadır.Gereç ve Yöntem: Otuz beş polikistik over sendromlu hasta ile 35 sağlıklı kadın çalışmaya dahil edildi. Katılımcıların demografik verilerinin yanı sıra açlık insülin, açlık kan şekeri, kolesterol değerleri, tam kan sayımı parametreleri, menstruasyonun erken foliküler dönemindeki hormon, tümör nekröz faktör alfa (TNFα) ve yüksek duyarlılıklı C-reaktif protein (hsCRP) değerleri karşılaştırıldı. Ayrıca, vücut kitle indeksine göre de subgrup analizi yapıldı.Bulgular: Katılımcıların yaş ve BMI ortalaması sırasıyla 27,2±5,71 ve 24,8±4,39 olarak hesaplandı. polikistik over sendromlu ve sağlıklı grup karşılaştırıldığında; yaş, bel/kalça oranı, TNFα, hsCRP, hemoglobin, HOMA-IR, FSH, LH, LH/FSH ve TSH değerleri anlamlı farklılık göstermektedir (p<0,05). İki grup arasında monosit/HDL (M/HDL) oranındaki farklılık istatiksel olarak anlamlı değildi. TNFα ile hsCRP’nin tanısal performansına bakıldığında ise; TNFα’nın 33,71 pg/ml değeri için sensitivite %69, spesifite %86, pozitif prediktif değer %68,6, negatif prediktif değer %85,7 iken, hsCRP’nin 3,82 mg/L değeri için sensitivite %91, spesifite %91, pozitif prediktif değer %91,4, negatif prediktif değer %91,4 olarak saptandı.Sonuç: TNFα ve hsCRP (kronik inflamasyon), polikistik over sendromu hastalarındaki hiperandrojenizmin patogenezinde rol oynamaktadır..

Anahtar Kelimeler:

Polikistik over sendromu, insülin direnci, inflamasyon

Serum levels of inflammatory markers and monocyte to high density lipoprotein ratio in polycystic ovary syndrome

Aim: This study aims to evaluate the difference between TNFα, hsCRP and M/HDL levels in polycystic ovary syndrome patients and healthy women.Material and Method: Thirty-five polycystic ovarian syndrome patients and 35 healthy women were included in the study. In addition to the demographic data of the participants, fasting insulin, fasting blood glucose, cholesterol values, complete blood count parameters, hormone in the early follicular period of menstruation, tumor necrosis factor alpha and high sensitivity C-reactive protein values were compared. In addition, subgroup analysis was performed according to body mass index.Results: The mean age and BMI of the participants were calculated as 27.2±5.71 and 24.8±4.39, respectively. When polycystic ovarian syndrome and healthy group are compared; age, waist/hip ratio, TNFα, hsCRP, hemoglobin, HOMA-IR, FSH, LH, LH/FSH and TSH values show significantly difference (p<0.05). The difference in monocyte/HDL (M/HDL) ratio between the two groups was not statistically significant. When the diagnostic performance of hsCRP with TNFα was evaluated; TNFα (for 33,71 pg/ml value) and hsCRP (for 3,82 mg/L value) respectively had sensitivity 69%, 91%; specifity 86%, 91%; positive predicitve value 68.6%, 91.4%and negative predictive value 85.7%, 91.4%.Conclusion: TNFα and hsCRP (chronic inflammation) play a role in the pathogenesis of hyperandrogenism in polycystic ovarian syndrome patients.

Keywords:

Polycystic ovary syndrome, insulin resistance, inflammation,

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