Tolga DÜZENLİ, Alpaslan TANOĞLU, Zafer KÜÇÜKODACI

Oldukça nadir bir gastrik lezyon: gastritis cystica profunda

Gastritis cystica profunda (GCP), kansere benzer bir görünüme sahip nadir, iyi huylu bir lezyondur. Bu lezyon mide mukozasında lokalizedir ve polipoid hiperplazi veya ülsere mukozal lezyon ve midenin submukozasına yayılan mukozal bezlerin kistik dilatasyonu ile karakterizedir. GCP'nin kesin etiyolojisi ve patogenezi hala tam olarak açıklanamamıştır. Bu olgu sunumunda, üst gastrointestinal sistem endoskopi incelemesi sonrası GCP tanısı alan, proton pompa inhibitörüne dirençli üst gastrointestinal semptomları olan 70 yaşında bir kadın olguyu sunuyoruz. Nadir görülen bu benign antite, gastrik mural kitle lezyonlarının ayırıcı tanısında akılda tutulmalıdır.

Anahtar Kelimeler:

gastrik lezyon, endoskopi, gastritis cystica profunda

An extremely rare gastric lesion: gastritis cystica profunda

Gastritis cystica profunda (GCP) is an uncommon, benign lesion which looking a cancer-like lesion. This lesion is localized in gastric mucosa and characterized by polypoid hyperplasia or ulcerated mucosal lesion and cystic dilatation of the mucosal glands spreading into the submucosa of the stomach. Exact etiology and pathogenesis of GCP is still incompletely explained. In this case report we present a case of 70-year-old female with proton pump inhibitor resistant upper gastrointestinal symptoms who was diagnosed as GCP after upper gastrointestinal system endoscopy examination. This rare benign entity should be kept in mind in the differential diagnosis of gastric mural mass lesions.

Keywords:

gastric lesion, endoscopy, gastritis cystica profunda,

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Littler ER, Gleibermann E. Gastritis cystica polyposa. (Gastric mucosal prolapse at gastroenterostomy site, with cystic and infiltrative epithelial hyperplasia) Cancer 1972; 29: 205–9.
Franzin G, Novelli P. Gastritis cystica profunda. Histopathology 1981; 5: 535–47.
Butt MO, Luck NH, Hassan SM, Abbas Z, Mubarak M. Gastritis profunda cystica presenting as gastric outlet obstruction and mimicking cancer: A case report. J Transl Int Med 2015; 3: 35-7.
Moon SY, Kim KO, Park SH, et al. Gastritis cystica profunda accompanied by multiple early gastric cancers. Korean J Gastroenterol 2010; 55: 325-30.
Ozenc AM, Ruacan S, Aran O. Gastritis cystica polyposa. Arch Surg. 1988; 123: 372–3.
Tuncer K, Alkanat M, Musoglu A, Aydin A. Gastritis cystica polyposa found in an unoperated stomach: An unusual case treated by endoscopic polypectomy. Endoscopy 2003; 35: 882.
Park JS, Myung SJ, Jung HY, et al. Endoscopic treatment of gastritis cystica polyposa found in an un-operated stomach. Gastrointest Endosc 2001; 54: 101–3.
Park CH, Park JM, Jung CK, et al. Early gastric cancer associated with gastritis cystica polyposa in the unoperated stomach treated by endoscopic submucosal dissection. Gastrointest Endosc 2009; 69: e47–50.
Aoyagi K, Koufuji K, Yano S, et al. Two cases of cancer in the remnant stomach derived from gastritis cystica polyposa. Kurume Med J 2000; 47: 243–8.
Choi MG, Jeong JY, Kim KM, et al. Clinical significance of gastritis cystica profunda and its association with Epstein-Barr virus in gastric cancer. Cancer 2012; 118: 5227–33.
Soares JB, Bastos P, Goncalves R. Menetrier disease with antrum polyposis and gastritis cystica profunda. Endoscopy 2012; 44: E56–7.
Yamashita M, Hirokawa M, Nakasono M, et al. Gastric inverted hyperplastic polyp report of four cases and relation to gastritis cystica profunda. APMIS 2002; 110: 717–23.