Kardiyopulmoner arrest ile sonuçlanan metformin ilişkili laktik asidoz: nadir bir olgu
Metformin, tip 2 diabetes mellitus tedavisinde birinci basamak ajan olarak yaygın olarak kullanılan oral hipoglisemik bir ilaçtır. Son zamanlarda yapılan çalışmalarda, normal aralıkta hafif veya orta derecede böbrek yetmezliği olan hastaların metformin ilaç düzeyleri normal bulundu ve ayrıca laktat düzeyleri normal sınırlarda bulundu. Ancak, hastanın böbrek fonksiyonu, karaciğer yetmezliği veya akut enfeksiyonu kötüleşmesi durumunda klinik önemi artar. Bu durumlarda, ilaç seviyeleri, yaşamı tehdit eden laktik asidozu arttırabilir. Biz burada kardiyopulmoner arrest ile sonuçlanan bir metformin ilişkili laktik asidoz olgusunu sunuyoruz.
Anahtar Kelimeler:
Metformin, laktik asidoz, kardiyopulmoner arrest
Metformin associated lactic acidosis resulted in cardiopulmonary arrest: a rare case
Metformin is an oral hypoglycemic drug which is commonly used as a first-line agent in the treatment of type 2 diabetes mellitus. In recent studies, metformin drug levels of the patients with mild or moderate renal impairment were found in normal range and also lactate levels were found in normal range. But it’s clinical importance increases when the patient had worsening renal function, hepatic insufficiency or acute infection. In these situations, drug levels can increase lactic acidosis leading to life threatening. Here we present a case of metformin associated lactic acidosis resulted in cardiopulmonary arrest.
Keywords:
Metformin, lactic acidosis, cardiopulmonary arrest,
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- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 2018
- Yayıncı: MediHealth Academy Yayıncılık
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Kardiyopulmoner arrest ile sonuçlanan metformin ilişkili laktik asidoz: nadir bir olgu