Hiponatremi ve uygunsuz antidiüretik hormon salınımı sendromu ile ilişkili sodyum valproat: bir olgu sunumu

Sodyum valproat, nörolojik ve psikiyatrik hastalıklarda kullanılan ve titreme, halsizlik, Reye benzeri sendrom, karaciğer yetmezliği, trombositopeni, pankreatit gibi yan etkileri olan bir ilaçtır. Hiponatremi, sodyum valproatın bir başka ciddi yan etkisidir. Burada, sodyum valproat ile ilişkili hiponatremi gelişen bir hastayı ele aldık.

Sodium valproate in association with hyponatremia and syndrome of inappropriate secretion of antidiuretic hormone: a case report

Sodium valproate is a drug used in neurological and psychiatric diseases and has side effects such as tremor, drowsiness, Reye-like syndrome, hepatic failure, thrombocytopenia, pancreatitis. Hyponatremia is another serious side effect of sodium valproate. Here, we report the case of a patient with hyponatremia associated with sodium valproate.

___

  • 1. Orum MH, Kalenderoglu A, Egilmez OB, Ozen ME, Kapici Y. Hyponatremia associated with repeated use of sodium valproate. Psychiatry and Behavioral Sciences 2018; 8: 93-4.
  • 2. Lu X, Wang X. Hyponatremia induced by antiepileptic drugs in patients with epilepsy. Expert Opin Drug Saf 2017; 16: 77-87.
  • 3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed.; Author: Washington, DC, 2013.
  • 4. Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of Naranjo Adverse Drug Reactions Probability Scale. Psychiatry and Clinical Psychopharmacology 2017; 27: 205-6.
  • 5. Harrois A, Anstey JR. Diabetes insipidus and syndrome of inappropriate antidiuretic hormone in critically III patients. Crit Care Clin 2019; 35: 187-200.
  • 6. Miyaoka T, Seno H, Itoga T, Kishi T, Ishino H, Horiguchi J. Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone. International Clinical Psychopharmacology 2001; 16: 59-61.
  • 7. Isbister GK, Balit CR, Whyte IM, Dawson A. Valproate overdose: a comparative cohort study of self-poisonings. Br J Clin Pharmacol 2003; 55: 398-404.
  • 8. Grynnerup A, Fernandez IS, Hernandez JC, Martinez AD, Lopez JM, Garcia-Alix A. A severe valproate overdose with complete recovery in a newborn. Journal of Child Neurology 2012; 27: 1072-6.
  • 9. Edwards IR, Biriell C. Harmonisation in pharmacovigilance. Drug Saf 1994; 10: 93-102.
  • 10. Ozen ME, Orum MH, Kalenderoglu A. Difficult patient in psychiatry practice: A case-control study. Adıyaman Üni Sağlık Bilimleri Derg 2018; 4: 1064-73.