Faruk YILDIZ, Aykut TURHAN, Fatih SÖNMEZ, İdris BAYDAR, Şenay DURMAZ CEYLAN, Mehmet ÖZTÜRK, Aydın ÇİFCİ, Betül GÜZEL, Ayşe ÇARLIOĞLU

Gestasyonel diyabette lipid düzeylerinin incelenmesi

Amaç: Anormal lipid profilleri gestasyonel diabetes mellitus (GDM) ile ilişkilendirilmiştir. Biz gestasyonel diyabette lipid profilini incelemeyi amaçladık. Metod: Çalışmamıza 127 GDM’li ve kontrol grubu olarak benzer BMİ, gebelik haftası ve yaş grubundan 30 sağlıklı gebe dahil edildi. Kan örnekleri12 saat açlıktan sonra alındı. Trigliserid, Total Kolesterol, yüksek yoğunluklu lipoprotein(HDL-K)plazma konsantrasyonları kolesterol enzimatik testlerle ölçüldü. Düşük yoğunluklu lipoprotein kolesterol(LDL-K) Friedewald'ın formülü ile hesaplandı.Bulgular: Trigliserid, Total Kolesterol ve LDL-K düzeyleri gebelikte artmış olarak bulundu. Ancak istatistiksel olarak anlamlı değildi. Hdl-k GDM grubunda kontrol ile karşılaştırılınca istatistiksel olarak anlamlı bir şekilde düşük bulundu. Logistik regresyon yapıldığında HDL’nin GDM’de kontrole göre düşük olması yaş, BMİ, gebelik haftasından bağımsız olarak bulundu. Roc analiz yapıldığında HDL < 70 mg/dl GDM’yi %83 spesifite, %64 sensivite ile predikte ettiği görüldü. Sonuç: Düşük HDL-C konsantrasyonları, GDM riskinde artış ile anlamlı şekilde ilişkiliydi. Total kolesterol, LDL-C, TG değerlerinde anlamlı yükselmeler görülmedi.

Anahtar Kelimeler:

Gestasyonel diyabetes mellitus (gdm), Lipid düzeyleri, Total kolesterol, Hdl-k, Ldl-k, Trigliserit

Investigation of gestational diabetic lipid levels

Aim: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM). We aimed to investigatethe lipid profile in gestational diabetes.Methots: This study was included 127 GDM and 30 healthy pregnant women to control group, similar BMI, gestational week and age group. Total cholesterol, high density lipoprotein (HDL-C) plasma concentrations were measured by cholesterol enzymatic tests. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula.Findings: Triglyceride, Total Cholesterol and LDL-C levels were found to be increased in pregnancy. However, it was not statistically significant. GDM compared with the control group in HDL-C were statistically significantly lower. When logistic regression was performed, HDL was lower than GDM control, regardless of age, BMD, gestational week. When Roc analysis was performed, it was seen that HDL <70 mg / dL GDM was predicted with 83% specificity and 64% sensitivity. Results: Low HDL-C concentrations were significantly associated with an increased risk of GDM. Total cholesterol, LDL-C, TG values were not significantly elevated.

Keywords:

Gestasyonel diyabetes mellitus (gdm), Lipid düzeyleri, Total kolesterol, Hdl-k, Ldl-k, Trigliserit,

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Journal of Health Sciences and Medicine-Cover

Yayın Aralığı: Yılda 6 Sayı
Başlangıç: 2018
Yayıncı: MediHealth Academy Yayıncılık

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