Gökhan GÖKALP, Nail Burak ÖZBEYAZ, Murat Oguz ÖZİLHAN

Evaluation of the relationship between mitral annular calcification and triglyceride-glucose index

Aims: Mitral annular calcification (MAC) is an echocardiographic condition with a multicomponent etiopathogenesis, one of which is insulin resistance. Triglyceride-glucose (TyG) index is an excellent biochemical parameter that has proven itself in determining insulin resistance in recent years. This study aims to reveal the relationship between the TyG index and the presence of MAC. Methods: The study included 159 patients with MAC and 167 control group. The control group has similar demographic characteristics such as age, gender, presence of hypertension (HT), and diabetes mellitus with the MAC group. TyG index was calculated as a formula: ln[fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. Results: The mean age of the patients was 74.2 and 48.2% of the patients were male. Coronary artery disease (CAD) (p: 0.031), glucose (p:0.001), total cholesterol (p:0.009), low-density lipoprotein (LDL) (p:0.004), triglyceride (TG) (p <0.001) levels and TyG index (p <0.001) were higher in MAC group. In the multivariate regression analysis, TG (p:0.004) and TyG index (p<0.001) were found to be independent risk factors. As a result of the ROC analysis, the cut-off value for estimating MAC was found to be 8.81 [(sensitivity: 77.3%, specificity: 76.5%, AUC (95% CI) 0.756 (0.704-0.807) p<0.001)]. Conclusion: In this study, a high TyG index was found to be an independent risk factor for MAC. The TyG index was found to be a better biomarker than TG and glucose alone in predicting MAC. Further extensive studies are necessary to determine the importance and use of TyG in MAC.

Keywords:

Mitral annular calcification, insulin resistance, triglyceride-glucose index,

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