Assessment of vitamin D deficiency and hyperparathyroidism in metabolically healthy and unhealthy obese patients

Aims: This study aimed to compare the levels of vitamin D in metabolically healthy (MHO) and metabolically unhealthy obese (MUO) individuals and determine if there are differences between these two groups concerning vitamin D deficiency and hyperparathyroidism. Methods: A total of 263 obese female patients were included in the study and divided into two groups based on metabolic syndrome diagnostic criteria. Biochemical and anthropometric data obtained after a 12-hour fasting period were analyzed. Results: Among the patients, the average 25-OH vitamin D level was 10.9±6.5 ng/ml. A total of 242 patients (92%) had vitamin D deficiency, and 132 patients (50.2%) were diagnosed with hyperparathyroidism. Significant differences were found in vitamin D (p=0.003) and uric acid (p<0.001) levels between the MHO and MUO groups. Additionally, the groups with vitamin D deficiency showed significantly different glucose (p=0.026) and homeostatic model assessment for insulin resistance (p=0.042) values. Patients with hyperparathyroidism had higher waist circumference (p<0.001), waist-to-hip ratio (p=0.018), BMI (p=0.006), and systolic (p=0.001) and diastolic (p<0.001) blood pressure values compared to those with normal parathyroid hormone levels. Conclusion: The study emphasizes the importance of monitoring vitamin D deficiency and hyperparathyroidism in obese patients, as these conditions are more prevalent in this population and might be associated with metabolic syndrome parameters, increasing cardiometabolic risk.

Keywords:

Vitamin D deficiency, obesity, hyperparathyroidism metabolic syndrome, cardiovascular disease,

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