The efficiency of HALP score, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in predicting mortality in intensive care patients
Objective: The HALP Score, which is a combination of hemoglobin, albumin, lymphocytes, and platelets, is a new index that shows nutritional status and systemic inflammation, provides information about patient prognosis. In this study, we aimed to investigate the relationship of HALP score, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR) and with poor prognosis in intensive care patients.
Material and Method: Our study was designed retrospectively on patients admitted from the emergency department (ED) to the intensive care unit (ICU). HALP scores, PLR and NLR values were calculated from the hemoglobin, albumin, lymphocyte, platelet and neutrophil values taken from the patients within 24 hours. One-week and three-month mortality were determined as poor outcomes. The relationship between results and poor outcomes was investigated.
Results: A total of 250 patients were included in the study. The median age of the patients was 72.5%, and 43.6% (n=109) were female. When the variables between survivors and non-survivors were compared, NLR was found to be significantly higher in non-survivors. In addition, there was a significant difference between the two groups in terms of both one-week and three-month mortality regarding age, albumin, lymphocyte, and thrombocyte values. When we analyzed the diagnostic performances of HALP Score, NLR, and PLR for one-week and three-month mortality, only NLR showed significant diagnostic performance. The optimal cut-off point for NLR for both one-week and three-month mortality was 8.22 (for one-week mortality: AUC=0.598, p=0.007; for three-month mortality: AUC=0.592, p=0.011).
Conclusion: It was observed that the HALP score was not an effective parameter in predicting prognosis in intensive care patients. It is thought that NLR has a significant relationship with one-week and three-month mortality and can be used as an effective parameter in the prediction of prognosis in intensive care patients.
___
- Strand K, Flaatten H. Severity scoring in the ICU: a review. Acta Anaesthesiol Scand 2008; 52: 467–78.
- Jeong S. Scoring systems for the patients of intensive care unit. Acute Crit Care 2018; 33: 102–4.
- Juneja D, Singh O, Nasa P, Dang R. Comparison of newer scoring systems with the conventional scoring systems in general intensive care population. Minerva Anestesiol 2012; 78: 194–200.
- Vincent J-L, Moreno R. Clinical review: scoring systems in the critically ill. Crit Care 2010; 14: 207.
- Templeton AJ, McNamara MG, Šeruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 2014; 106: dju124.
- Çetinkaya HB, Çay F. Acil servis başvurularında basit ve şiddetli kolesistit ayırımında NLO kullanılabilirliği. Van Tıp Derg 2021; 28: 502-6.
- Guo Y, Shi D, Zhang J, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel significant prognostic factor for patients with metastatic prostate cancer undergoing cytoreductive radical prostatectomy. J Cancer 2019; 10: 81-91.
- Peng D, Zhang CJ, Tang Q, et al. Prognostic significance of the combination of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients with renal cell carcinoma after nephrectomy. BMC Urol 2018; 18: 20.
- Chen X, Xue L, Wang W, et al. Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study. Oncotarget 2015; 6: 41370–82.
- Jiang H, Li H, Li A, et al. Preoperative combined hemoglobin, albumin, lymphocyte and platelet levels predict survival in patients with locally advanced colorectal cancer. Oncotarget 2016; 7: 72076–83.
- Tian M, Li Y, Wang X, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score ıs associated with poor outcome of acute ıschemic stroke. Front Neurol 2021; 11: 610318.
- Reininger AJ, Bernlochner I, Penz SM, et al. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010; 55: 1147–58.
- Xu SS, Li S, Xu HX, et al. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroenterol 2020; 26: 828-38.
- Karagoz I, Yoldas H. Platelet to lymphocyte and neutrophil to lymphocyte ratios as strong predictors of mortality in intensive care population. Rev Assoc Med Bras 2019; 65: 633-6.
- Altas OF, Kizilkaya M. The effects of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and prognostic markers in determining the mortality in patients diagnosed with pneumonia in ıntensive care. Medeni Med J 2021; 36: 130-7.
- Kutlucan L, Kutlucan A, Basaran B, et al. The predictive effect of initial complete blood count of intensive care unit patients on mortality, length of hospitalization, and nosocomial infections. Eur Rev Med Pharmacol Sci 2016; 20: 1467-73.
- de Almeida JP, Vincent JL, Galas FR, et al. Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology 2015; 122: 29-38.
- Peng D, Zhang CJ, Gong YQ, et al. Prognostic significance of HALP (hemoglobin, albumin, lymphocyte and platelet) in patients with bladder cancer after radical cystectomy. Sci Rep 2018; 8: 794.
- Feng JF, Wang L, Yang X. The preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) score is a useful predictor in patients with resectable esophageal squamous cell carcinoma. Bosn J Basic Med Sc 2021; 21: 773-81.
- Yang W, Wang X, Zhang W, et al. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are 2 new inflammatory markers associated with pulmonary involvement and disease activity in patients with dermatomyositis. Clin Chim Acta 2017; 465: 11–6.
- Yao C, Liu X, Tang Z. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD. Int J Chron Obstruct Pulmon Dis 2017; 12: 2285-90.
- Biyikli E, Kayipmaz AE, Kavalci C. Effect of platelet-lymphocyte ratio and lactate levels obtained on mortality with sepsis and septic shock. Am J Emerg Med 2018; 36: 647-50.
- Lui CT, Ching WM, Tsu, KL, et al. Feasibility of predictive model by clinical and laboratory parameters for risk stratification of geriatric abdominal pain. Hong Kong J Emerg Med 2019; 26: 242-9.
- Gharebaghi N, Valizade Hasanloei MA, Medizadeh Khalifani A, Pakzad S, Lahooti D. Neutrophil-to-lymphocyte ratio in patients with gram-negative sepsis admitted to intensive care unit. Anaesthesiol Intensive Ther 2019; 51: 11-6.
- Liu Y, Zheng J, Zhang D, Jing L. Neutrophil-lymphocyte ratio and plasma lactate predict 28-day mortality in patients with sepsis. J Clin Lab Anal 2019; 33: e22942.
- King AH, Mehkri O, Rajendram P, Wang X, Vachharajani V, Duggal A. A high neutrophil-lymphocyte ratio ıs associated with ıncreased morbidity and mortality in patients with coronavirus disease 2019. Crit Care Explor 2021; 3: e0444.
- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 2018
- Yayıncı: MediHealth Academy Yayıncılık
Sayıdaki Diğer Makaleler
Vedat TAN, Alparslan Kemal TUZCU, Zafer PEKKOLAY
Comparison of the tube thoracostomy techniques on treatment in COVID-19 patients with pneumothorax
Rezan KARAALİ, Hasan ERSÖZ, Pınar Yeşim AKYOL, Guner YURTSEVER, Fatih TOPAL
Sina COŞKUN, Hikmet ÇİNKA, İsmail BÜYÜKCERAN, Göksel ŞAHİNER, Alparslan YURTBAY, Furkan ERDOĞAN, Ahmet PİŞKİN
Ayşe AYYILDIZ, Nurdan ÇOBANER, Birgül YELKEN
Ali Burak BİNBOĞA, Gökalp GÜZEL, Mehmet ONAY, Çetin Murat ALTAY
Ali Onur KELEŞ, Sezgi ŞAHİN DUYAR, Funda AKSU, Selma FIRAT
Sanem KAYHAN, Fatih KİVRAKOGLU, Aysenur Miray YARLIOGLU, Mercan TAŞTEMUR, İbrahim AKDAĞ