SCUBE-1 as a novel predictor of thromboembolic event

SCUBE-1 as a novel predictor of thromboembolic event

SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.
Journal of Experimental and Clinical Medicine-Cover
  • Yayın Aralığı: 5
  • Başlangıç: 1980
  • Yayıncı: Ondokuz mayıs Üniversitesi Tıp Fakültesi