Can AKGÜN, Bekir KURU, Saim Savaş YÜRÜKER, Ufuk KARABACAK, Necati ÖZEN

Prognostic Factors Affecting Survival in Breast Cancer Patients Age 40 Or Younger

Objectives: The aims of this study were to identify the factors affecting survival and disease-free survival (DFS) in invasive breast cancer patients who underwent surgery for breast cancer age 40 or younger. Methods: Medical records of 216 women with breast carcinoma at age 40 or younger who underwent surgery at our Institution between October 2005 and May 2017 were retrospectively reviewed. One hundred and eighty eight invasive breast cancer patients that were eligible were categorized according to their clinical and pathological features. Univariate analyses of survival and DFS were performed by the Kaplan–Meier method and the log-rank test. Independent prognostic and predictive factors affecting survival and DFS were assessed by Cox regression proportional hazard method. Results: 10-year survival and DFS were 85 and 74%, respectively. Axillary involvement, pathologic tumor size, HER 2 + subtype and Triple Negative subtype were found to be the prognostic factors that independently affected survival and DFS. Conclusions: The prognosis is worse in patients with axillary involvement, tumors larger than 2 cm, and HER 2+ and Triple Negative subtypes. These adverse prognostic factors should be considered during treatment and follow-up of patients age 40 or younger.

Keywords:

Breast cancer, prognosis, survival, disease-free survival, breast neoplasms,

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