Miscarriage in a patient with Glanzmann Thrombasthenia and low ovarian reserve: a case report

Miscarriage in a patient with Glanzmann Thrombasthenia and low ovarian reserve: a case report

Glanzmann thrombasthenia (GT) is an autosomal recessive hemorrhagic disorder mostly complicated by mucocutaneous bleeding. The severity of this bleeding disorder varies from mild bruising to frequent severe bleeding. Prepartum, peripartum and postpartum bleeding risks are increased in these patients. In addition to the hemorrhagic complications which endanger maternal and fetal wellbeing, the risk of miscarriage is increased due to maternal antibodies to the platelets which are also found on conceptus-derived trophoblast (placental) cells. This case report is about a patient with GT, complicated by infertility, low ovarian reserve, HPV positivity and bilateral dermoid cyst, who had a miscarriage in 7+1 week.

___

  • 1. Nurden AT. Glanzmann thrombasthenia. Orphanet J Rare Dis. 2006 ;1(1):10.
  • 2. Poon MC, Di Minno G, d’Oiron R, Zotz R. New Insights Into the Treatment of Glanzmann Thrombasthenia. Transfusion Medicine Reviews. 2016 ;30(2):92–9.
  • 3. Clemetson KJ. Platelets and Primary Haemostasis. Thrombosis Research. 2012 ;129(3):220–4.
  • 4. Wijemanne A, Watt-Coote I, Austin S. Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes. Obstet Med. 2016 ;9(4):169–70.
  • 5. Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, et al. Glanzmann thrombasthenia: genetic basis and clinical correlates. Haematologica. 2020 ;105(4):888–94.
  • 6. Nurden AT. Acquired Antibodies to α IIbβ3 in Glanzmann Thrombasthenia: From Transfusion and Pregnancy to Bone Marrow Transplants and Beyond. Transfusion Medicine Reviews. 2018 ;32(3):155–64.
  • 7. Yougbaré I, Tai WS, Zdravic D, Oswald BE, Lang S, Zhu G, et al. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun. 2017 ;8(1):224.
  • 8. Nurden A, Pillois X, Fiore M, Heilig R, Nurden P. Glanzmann Thrombasthenia-Like Syndromes Associated with Macrothrombocytopenias and Mutations in the Genes Encoding the αIIbβ3 Integrin. Semin Thromb Hemost. 2011 ;37(06):698–706.
  • 9. Busnelli A, Somigliana E, Cirillo F, Levi-Setti PE. Is diminished ovarian reserve a risk factor for miscarriage? Results of a systematic review and meta-analysis. Human Reproduction Update. 2021 ;27(6):973–88.
  • 10. Lyttle Schumacher BM, Jukic AMZ, Steiner AZ. Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies. Fertility and Sterility. 2018 ;109(6):1065-1071.e1.
Journal of Experimental and Clinical Medicine-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1980
  • Yayıncı: Ondokuz mayıs Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Evaluation Of Mammographic Features In Women With Adenomyosis

Nezaket KADIOĞLU, Ayçağ YORGANCI, Harika GÜMGÜMCÜ, Mahmut Kuntay KOKANALI, Şebnem ÖZYER, Yaprak ÜSTÜN

Establishment of Biocidal Activity Evaluation Study Protocol in Healthcare Facility for Routine Monitoring of Antibacterial Activity of Disinfectants

Mostafa EİSSA

EXAMINING THE PREVALENCE OF ALLERGIC DISEASES IN HAIRDRESSERS IN THE BLACK SEA REGION

Nida KIYICI, Recep SANCAK, Gonca HANCIOĞLU, Şefika İlknur KÖKÇÜ KARADAĞ

SIGNIFICANCE OF TISSUE OXYGENIZATION IN PATIENTS CONNECTED TO A MECHANICAL VENTILATOR

Fulya KÖSE, Bülent GÜNGÖRER, Hanifi ARSLAN, Abdullah Sadık GİRİŞGİN, Zerrin Defne DÜNDAR, Merve GÜVEN

The Effects of Sperm Parameters and Sperm DNA Damage on pregnancy outcomes of women undergoing intrauterine insemination

Murat ÖNAL, Müstecep KAVRUT, Nur DOKUZEYLÜL GÜNGÖR, Tuğba GÜRBÜZ

Comparison of the Effects of Acupressure and Ice massage in Primary Dysmenorrhea: A Randomized Controlled Trial

Naimeh POURRAMEZANİ, Maryam FİROUZABADİ, Fatemeh ALAVİ, Mohadeseh BALVARDİ, Moazameh Sadat RAZAVİ NASAB

Understanding physicians’ moral distress in the Covid 19 pandemic

Selin KESKİN KIZILTEPE, Asli KURTGÖZ

The comparison of the therapeutic effects of piroxicam gel and oral vitamin E in cyclic mastalgia

Razieh BEHZADMEHR, Tahmineh EZAZİ BOJNORDİ

Study of Bacteria Isolated from COVID-19 and Non-COVID-19 Intensive Care Units and Determination of Their Antibiotic Susceptibility Profiles

Çetin KILINÇ, Nilay COPLU, Melike YAŞAR DUMAN, Büşra ÇALIŞIR, Enis Fuat TÜFEKCİ, Muhammet GÜLHAN, Ayşe YILMAZ, Veysel Garani SOYLU

Sex-Related Differences in Anxiety in Experimental Functional Dyspepsia Induced by Chronic Stress

Osman SİNEN