Melatonin as a natural, non-addictive opiate can guarantee a well night-sleep, strengthens your immunity against many diseases and cancer, regulate reproductive activities, normalize cholesterol, and reduce the stressful emotions. The book about the melatonin includes 44 chapters and has a large perspective. In the first chapters, the authors argue that production, bioavailability, antioxidant features, pharmacological and clinical aspects of melatonin. Secondly, the experts clearly explain various effects of melatonin on the analgesia, peripheral nerve regeneration, adult hippocampal neurogenesis, epilepsy, differentiation of the neural stem cells, degenerative disc disease, osteoblastic and osteoclastic activities. Then, there are chapters about beneficial effects of melatonin in metabolic syndrome, pediatric diseases, glaucoma, sepsis, carcinogenesis, familial Mediterranean Fever, kidney and liver toxicity. In the book, some authors reported that melatonin have neuro-protective role on Alzheimer, Parkinson’s disease, neuropsychiatric or neurodegenerative disorders and stroke. Also in the book suggest that melatonin can keep neurons from the deleterious effects of perinatal hypoxia, ischemia and also toxicity of prions, dexamethasone or non–steroidal anti-inflammatory drugs. In summary, this book is must be read to find out qualified responses for the many questions about melatonin that what is the melatonin, how melatonin works, and how to use it, and what to expect its therapeutic future.