ABSTRACT Giant myomas of the uterus are uncommon, particularly in developed countries. A 58 years old schizophrenic woman admitted to hospital after realizing a bulging in her abdomen.Upon initial work up a solid mass occupying the whole abdomen was observed but USG scan was unable to visualize the uterus or ovaries.MRI showed the mass to have solid areas indicating that it may be myoma uteri.Patient was prepared for operation. Those with giant uterine leiomyomata are a very unique and represent a small portion of millions of women with fibroids. The knowledge of the diVerent clinical manifestation of these myomas may allow to face that with adequate perioperative care, in order to assure a carefully and successfully surgery, although sometimes a benign pathology may be not easy to suspect in a first time. J. Exp. Clin. Med., 2011; 28:122-123