The anticonvulsant hypersensitivity syndrome is defined as an idiosyncratic reaction cau¬sed by disturbed drug metabolism. Rash, hepatitis, eosinophilia, fever and lymphadenopathy are the main characteristics of this syndrome. Prognosis is poor in the severe cases with fulminant hepatic failure, where as it is good in mild cases with skin rash. The cases should be treated with prednisone and antihistamines. In this paper, 12-year-old girl with hypersensitivity syndrome induced by carbamazepine four weeks after therapy was presented.