Sezgin BİLGİN, F. Emre ÜSTÜN, Ali EKŞİ, Elif BENGİ ŞENER, İ. Serhat KOCAMANOĞLU, Binnur SARIHASAN

Postoperatif Bulantı Kusma Profilaksisinde Kullanılan Ondansetron ve Metoklopramidin EKG’de QT Aralığına Etkileri

Bu çalışmada ondansetron ile metoklopramidin QT aralığına etkilerini karşılaştırmak amaçlanmıştır. Çalışmaya 18–65 yaş arası, ASA I-II (American Society of Anesthesiologists) grubu 100 hasta alındı. Anestezi indüksiyonu propofol, remifentanil ve veküronyum ile sağlandıktan sonra idamede O2/kuru hava içinde %4–6 desfluran uygulandı. Entübasyondan sonra rasgele gruplardan birine ondansetron 4 mg/2ml (Grup-O), diğerine metoklopramid 10 mg/2ml (Grup-M) ve kontrol grubuna 2 ml serum fizyolojik (Grup-K) iv. verildi. Hastaların indüksiyon öncesi, entübasyon sonrası, ilaçlar uygulandıktan sonra operasyon süresince hemodinamik, solunumsal parametreleri ve ısı değerleri kaydedildi. Eş zamanlı EKG örnekleri alındı. EKG’de QT aralıkları ölçülüp, Bazzet formülüyle kalp hızına göre düzeltilmiş değerler (QTc) hesaplandı. Hasta grupları arasında demografik özelliklerde, kaydedilen vital bulgularda ölçüm dönemlerinde anlamlı fark bulunmadı (p>0.05). İndüksiyon öncesi bazal QTc değerlerinde gruplar arasında farklılık saptanmadı (p>0.05). Entübasyon sonrası QTc değerleri gruplarda sırasıyla Grup-K’da 13,2±11, Grup-O’da 20,4±8 ve Grup-M’de 19,0±10 ms uzadı (p

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